Determinants of raised C-reactive protein concentration in type 1 diabetes

被引:37
作者
Kilpatrick, ES
Keevil, BG
Jagger, C
Spooner, RJ
Small, M
机构
[1] Hull Royal Infirm, Dept Clin Biochem, Kingston Upon Hull HU3 2JZ, N Humberside, England
[2] Wythenshawe Hosp, Dept Clin Biochem, Manchester M23 9LT, Lancs, England
[3] Royal Preston Hosp, Dept Clin Biochem, Preston, Lancs, England
[4] Gartnavel Royal Hosp, Dept Clin Biochem, Glasgow, Lanark, Scotland
[5] Gartnavel Royal Hosp, Diabet Unit, Glasgow, Lanark, Scotland
关键词
D O I
10.1093/qjmed/93.4.231
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
As a marker of systemic inflammation, raised C-reactive protein (CRP) concentrations which are still within the normal range have been associated with an increased incidence of coronary heart disease (CHD) in non-diabetic subjects. This study aimed to establish potential determinants of raised CRP concentrations in type 1 diabetic patients. We used a sensitive assay to measure 'low-level' CRP concentrations in 167 type 1 patients (93M, 74F, median age 30 years, range 13-67). Stepwise multivariate analysis was used to relate these CRP levels to known cardiovascular risk factors and demographic data. Only six patients had established CHD (median CRP 3.34 mg/l vs. 0.83 mg/l, p = 0.032). In subjects without overt CHD, multivariate analysis showed increases in subject age (p = 0.0025), BMI (p = 0.001) and HbA, (p = 0.012) to be associated with a higher CRP concentration, as was female sex (p = 0.026) and a history of CHD in a first-degree relative (p = 0.018, n = 57). The duration of diabetes, current smoking status, presence of microvascular complications, lipid status and presence of hypertension were unrelated. This study suggests that some of the risk factors associated with CHD in type 1 patients are also independently predictive of high CRP concentrations. The reasons for this, and whether intervention would prove useful, require further investigation.
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页码:231 / 236
页数:6
相关论文
共 25 条
[1]  
Adler AI, 1999, DIABETOLOGIA, V42, pA187
[2]   Diabetes and long-term risk of mortality from coronary and other causes in middle-aged Swedish men - A general population study [J].
Adlerberth, AM ;
Rosengren, A ;
Wilhelmsen, L .
DIABETES CARE, 1998, 21 (04) :539-545
[3]   Is Helicobacter pylori a factor in coronary atherosclerosis? [J].
Danesh, J ;
Koreth, J ;
Youngman, L ;
Collins, R ;
Arnold, JR ;
Balarajan, Y ;
McGee, J ;
Roskell, D .
JOURNAL OF CLINICAL MICROBIOLOGY, 1999, 37 (05) :1651-1651
[4]  
DCCT Res Grp, 1988, DIABETES, V37, P476
[5]  
Diabet Control Complications Trial DCCT Res Grp, 1995, AM J CARDIOL, V75, P894
[6]  
Gallagher D, 1996, AM J EPIDEMIOL, V143, P228, DOI 10.1093/oxfordjournals.aje.a008733
[7]  
Haverkate F, 1997, LANCET, V349, P462, DOI 10.1016/S0140-6736(96)07591-5
[8]   TUMOR-NECROSIS-FACTOR-ALPHA - A KEY COMPONENT OF THE OBESITY-DIABETES LINK [J].
HOTAMISLIGIL, GS ;
SPIEGELMAN, BM .
DIABETES, 1994, 43 (11) :1271-1278
[9]   INCREASED ADIPOSE-TISSUE EXPRESSION OF TUMOR-NECROSIS-FACTOR-ALPHA IN HUMAN OBESITY AND INSULIN-RESISTANCE [J].
HOTAMISLIGIL, GS ;
ARNER, P ;
CARO, JF ;
ATKINSON, RL ;
SPIEGELMAN, BM .
JOURNAL OF CLINICAL INVESTIGATION, 1995, 95 (05) :2409-2415
[10]   DIABETES AND CARDIOVASCULAR-DISEASE - FRAMINGHAM-STUDY [J].
KANNEL, WB ;
MCGEE, DL .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1979, 241 (19) :2035-2038