Coriadienin, the first Annonaceous acetogenin with two double bonds isolated from Annona coriaceae

被引:24
作者
daSilva, ELM
Roblot, F
Mahuteau, J
Cave, A
机构
[1] UNIV PARIS 11, FAC PHARM, LAB PHARMACOGNOSIE, F-92296 CHATENAY MALABRY, FRANCE
[2] UNIV PARIS 11, FAC PHARM, BIOCIS, URA 1843 CNRS, SERV RMN, F-92296 CHATENAY MALABRY, FRANCE
来源
JOURNAL OF NATURAL PRODUCTS | 1996年 / 59卷 / 05期
关键词
D O I
10.1021/np960079e
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
A new Annonaceous acetogenin, coriadienin (1), has been isolated from the roots of Annona coriacea Mart. (Annonaceae). This structure is the first reported acetogenin containing two double bonds. Compound 1 showed potent cytotoxicity against VERO and KB cell lines. Compound 1 appears to play an important role in the biosynthetic pathway of mono- and bis-THF acetogenins, and it is proposed as a biogenetic precursor of coriacin. A known cytotoxic acetogenin, gigantetronenin, was also isolated from this plant.
引用
收藏
页码:528 / 530
页数:3
相关论文
共 15 条
  • [1] CAVE A, 1993, RECENT ADV PHYTOCHEM, V27, P167
  • [2] CAVE A, 1996, IN PRESS PROGR CHEM
  • [3] ANNONACEOUS ACETOGENINS - AN UPDATED REVIEW
    FANG, XP
    RIESER, MJ
    GU, ZM
    ZHAO, GX
    MCLAUGHLIN, JL
    [J]. PHYTOCHEMICAL ANALYSIS, 1993, 4 (01) : 27 - 48
  • [4] GIGANTETRONENIN AND GIGANTRIONENIN - NOVEL CYTOTOXIC ACETOGENINS FROM GONIOTHALAMUS-GIGANTEUS
    FANG, XP
    ANDERSON, JE
    SMITH, DL
    MCLAUGHLIN, JL
    WOOD, KV
    [J]. JOURNAL OF NATURAL PRODUCTS, 1992, 55 (11): : 1655 - 1663
  • [5] FANG XP, 1992, HETEROCYCLES, V34, P1075
  • [6] GONIOCIN FROM GONIOTHALAMUS-GIGANTEUS - THE FIRST TRI-THF ANNONACEOUS ACETOGENIN
    GU, ZM
    FANG, XP
    ZENG, L
    MCLAUGHLIN, JL
    [J]. TETRAHEDRON LETTERS, 1994, 35 (30) : 5367 - 5368
  • [7] Hui Yu-Hua, 1992, Natural Toxins, V1, P4, DOI 10.1002/nt.2620010104
  • [8] LAPREVOTE O, 1993, ANALUSIS, V21, P207
  • [9] ACETOGENINS FROM ANNONACEAE .16. FORMATION OF GAS-PHASE LITHIUM COMPLEXES FROM ACETOGENINS AND THEIR ANALYSIS BY FAST-ATOM-BOMBARDMENT MASS-SPECTROMETRY
    LAPREVOTE, O
    GIRARD, C
    DAS, BC
    CORTES, D
    CAVE, A
    [J]. TETRAHEDRON LETTERS, 1992, 33 (36) : 5237 - 5240
  • [10] LOCATION OF EPOXY RINGS IN A LONG-CHAIN ACETOGENIN BY FAST-ATOM-BOMBARDMENT AND LINKED SCAN (B/E) MASS-SPECTROMETRY OF LITHIUM-CATIONIZED MOLECULES .15.
    LAPREVOTE, O
    GIRARD, C
    DAS, BC
    LAUGEL, T
    ROBLOT, F
    LEBOEUF, M
    CAVE, A
    [J]. RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 1992, 6 (05) : 352 - 355