Fibroblast growth factors in epithelial repair and cytoprotection

被引:73
作者
Braun, S [1 ]
Keller, UAD [1 ]
Steiling, H [1 ]
Werner, S [1 ]
机构
[1] ETH, Dept Biol, Inst Cell Biol, CH-8093 Zurich, Switzerland
关键词
fibroblast growth factor; hepatectomy; keratinocyte growth factor; mucositis; reactive oxygen species; wound healing;
D O I
10.1098/rstb.2004.1464
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Growth factors are polypeptides that stimulate the division of certain cell types at low concentrations. Fibroblast growth factor (FGF) 7 (FGF-7) and its homologue FGF-10 act specifically on various types of epithelial cells including keratinocytes of the skin, intestinal epithelial cells and hepatocytes. In addition, FGF-7 and FGF-10 have been shown to be more than growth factors: they can protect epithelial cells from damaging effects induced, for example, by radiation and oxidative stress. Therefore, they are currently in clinical trials for the treatment of oral mucositis, a severe side-effect of cancer therapy characterized by painful inflammation and ulceration of the oral epithelium. To gain insight into the mechanisms of FGF-7/FGF-10 action in epithelial cells, we searched for genes that are regulated by these growth factors. Indeed, we identified genes that help us to explain the mechanisms that underlie the effects of FGF-7. Most interestingly, several genes were identified that are likely to mediate the cytoprotective effect of FGF-7 for epithelial cells in vitro and possibly also in injured and diseased tissues in vivo.
引用
收藏
页码:753 / 757
页数:5
相关论文
共 33 条
[1]  
Abraham J. A., 1996, MOL CELLULAR BIOL WO, P195
[2]   THE FGF FAMILY OF GROWTH-FACTORS AND ONCOGENES [J].
BASILICO, C ;
MOSCATELLI, D .
ADVANCES IN CANCER RESEARCH, 1992, 59 :115-165
[3]   Mouse fibroblast growth factor 10: cDNA cloning, protein characterization, and regulation of mRNA expression [J].
Beer, HD ;
Florence, C ;
Dammeier, J ;
McGuire, L ;
Werner, S ;
Duan, DR .
ONCOGENE, 1997, 15 (18) :2211-2218
[4]   Fibroblast growth factor 22 and its potential role during skin development and repair [J].
Beyer, TA ;
Werner, S ;
Dickson, C ;
Grose, R .
EXPERIMENTAL CELL RESEARCH, 2003, 287 (02) :228-236
[5]  
Brauchle M, 1996, AM J PATHOL, V149, P521
[6]   Nrf2 transcription factor, a novel target of keratinocyte growth factor action which regulates gene expression and inflammation in the healing skin wound [J].
Braun, S ;
Hanselmann, C ;
Gassmann, MG ;
Keller, UAD ;
Born-Berclaz, C ;
Chan, KM ;
Kan, YW ;
Werner, S .
MOLECULAR AND CELLULAR BIOLOGY, 2002, 22 (15) :5492-5505
[7]   Polycyclic aromatic hydrocarbon-DNA adducts in liver tissues of hepatocellular carcinoma patients and controls [J].
Chen, SY ;
Wang, LY ;
Lunn, RM ;
Tsai, WY ;
Lee, PH ;
Lee, CS ;
Ahsan, H ;
Zhang, YJ ;
Chen, CJ ;
Santella, RM .
INTERNATIONAL JOURNAL OF CANCER, 2002, 99 (01) :14-21
[8]   The effects of keratinocyte growth factor in preclinical models of mucositis [J].
Farrell, CL ;
Rex, KL ;
Chen, JN ;
Bready, JV ;
DiPalma, CR ;
Kaufman, SA ;
Rattan, A ;
Scully, S ;
Lacey, DL .
CELL PROLIFERATION, 2002, 35 :78-85
[9]   Increased expression of keratinocyte growth factor messenger RNA associated with inflammatory bowel disease [J].
Finch, PW ;
Pricolo, V ;
Wu, A ;
Finkelstein, SD .
GASTROENTEROLOGY, 1996, 110 (02) :441-451
[10]   The human homologue of a bovine non-selenium glutathione peroxidase is a novel keratinocyte growth factor-regulated gene [J].
Frank, S ;
Munz, B ;
Werner, S .
ONCOGENE, 1997, 14 (08) :915-921