Extragonadal teratocarcinoma in chimeric mice

被引：5

作者：

Blackshear, P ^{[1
]}

Mahler, J ^{[1
]}

Bennett, LM ^{[1
]}

McAllister, KA ^{[1
]}

Forsythe, D ^{[1
]}

Davis, BJ ^{[1
]}

机构：

[1] NIEHS, Res Triangle Pk, NC 27709 USA

来源：

VETERINARY PATHOLOGY | 1999年 / 36卷 / 05期

关键词：

chimera; embryonic stem cells; extragonadal teratocarcinoma; mice;

D O I：

10.1354/vp.36-5-457

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Chimeric mice often are created through the genetic manipulation of the mouse embryo in the process of developing animal models of disease. These mice have variable percentages of their somatic and germ cells derived from the donor embryonic stem cells and host blastocysts. In the development of mouse models deficient in the breast cancer susceptibility gene 2 (Brca2) or the 70-kd heat shock protein (Hsp70-2), 3-4-week-old chimeras developed single or multiple masses composed of both well-differentiated and poorly differentiated tissues derived from all three germ layers. These cases of extragonadal teratocarcinoma, a rarely reported tumor, may be related to the genetic predisposition of the 129/O1a mouse strain used to generate the embryonic stem cells.

引用

页码：457 / 460

页数：4

共 9 条

[1]

ARTZT K, 1978, LAB ANIM SCI, V28, P584

[2] Targeted gene disruption of Hsp70-2 results in failed meiosis, germ cell apoptosis, and male infertility [J].