Disorder breathes life into a DEAD motor

被引：7

作者：

Cavanaugh, Lorraine F. ^{[1
]}

Palmer, Arthur G., III

Gierasch, Lila M.

Hunt, John F.

机构：

[1] Columbia Univ, Dept Biol Sci, Fairchild Ctr 702A, New York, NY 10027 USA

[2] Columbia Univ, Dept Biochem & Mol Biophys, New York, NY 10032 USA

[3] Univ Massachusetts, Dept Biochem & Mol Biol, Amherst, MA 01003 USA

[4] Univ Massachusetts, Dept Chem, Amherst, MA 01003 USA

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2006年 / 13卷 / 07期

关键词：

D O I：

10.1038/nsmb0706-566

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

SecA is an essential eubacterial protein in which the ATPase motor from DEAD-box RNA helicases has adapted to function as a processive polypeptide pump. A new report suggests that a disorder-order transition in the DEAD-box motor is responsible for distinctive thermodynamic features of SecA's conformationally coupled ATPase cycle.

引用

页码：566 / 569

页数：5

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