Time course of endothelin-1 and nitrate anion levels after cardiopulmonary bypass in congenital heart defects

被引:27
作者
Hiramatsu, T [1 ]
Imai, Y [1 ]
Takanashi, Y [1 ]
Hoshino, S [1 ]
Yashima, M [1 ]
Tanaka, SA [1 ]
Chang, DH [1 ]
Nakazawa, M [1 ]
机构
[1] TOKYO WOMENS MED COLL,HEART INST JAPAN,DEPT CARDIOL,TOKYO 162,JAPAN
关键词
D O I
10.1016/S0003-4975(96)01055-7
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background. The endothelium-derived vasoconstrictor endothelin-1 (ET-1) may be involved in pulmonary hypertension (PH), but production of the endothelium-derived vasodilator nitric oxide (NO) after cardiopulmonary bypass (CPB) in congenital heart disease is unclear. Methods. Twenty patients (age, 4 months to 12 years) were divided into three groups: severe PH (mean pulmonary-to-systemic arterial pressure ratio >0.5) and high pulmonary now (n = 8), mild PH (mean pulmonary-to-systemic arterial pressure ratio <0.35) and high pulmonary flow (n = 6), and no PH and low pulmonary flow (n = 6). The mean pulmonary-to-systemic arterial pressure ratio was calculated and blood samples were taken, and NO3-, an NO metabolite, was measured. Results. Levels of ET-1 in the group with severe PH and high pulmonary now were higher than in the other groups until 6 hours after CPB, and NO3- was not changed significantly in the group with severe PH and high pulmonary now and or the group with mild PH and high pulmonary now during CPB. Endothelin-1 in the group with no PH and low pulmonary flow was higher than in the group with mild PH and high pulmonary flow after CPB, and NO3- in the group with no PH and low pulmonary now significantly decreased after CPB. A positive correlation was obtained between mean pulmonary-to-systemic arterial pressure ratio and ET-1 (r = 0.742 before CPB; r = 0.689 after CPB). Conclusions. Imbalance between increased ET-1 and constant NO after CPB in the group with severe PH and high pulmonary flow could contribute to dominant effects of ET-1, which may injure the lung. The increased ET-1 and the decreased NO after CPB in the group with no PH and low pulmonary flow may induce a mechanism of protective vasoconstriction against an acute increase in pulmonary flow. (C) 1997 by The Society of Thoracic Surgeons.
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页码:648 / 652
页数:5
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