Synthesis and technetium-99m labeling of cyclic gp IIB/IIIA receptor antagonists conjugated to 4,5-bis(mercaptoacetamido)-pentanoic acid (MAPT)

被引：13

作者：

Rajopadhye, M

Edwards, DS

Bourque, JP

Carroll, TR

机构：

[1] Discovery, Radiopharmaceutical Div., DuPont Merck Pharmaceutical Company, N. Billerica, MA 01862

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 15期

关键词：

D O I：

10.1016/0960-894X(96)00264-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of cyclic Arg-Gly-Asp GP Ilb/IIIa receptor antagonists conjugated to 4,5-bis(S-1-ethoxyethyl-mercaptoacetamido)pentanoic acid is reported. The corresponding Tc-99m-labeled complexes were prepared by exchange labeling with Tc-99m-glucoheptonate. This indirect labeling approach is an alternative to the preformed chelate approach using mapt. Copyright (C) 1996 The DuPont Merck Pharmaceutical Company.

引用

页码：1737 / 1740

页数：4

共 12 条

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