Reduced spontaneous activity in the dorsal cochlear nucleus of Scn8a mutant mice

被引:13
作者
Chen, K
Sprunger, LK
Meisler, MH
Waller, HJ
Godfrey, DA
机构
[1] Med Coll Ohio, Dept Otolaryngol, Toledo, OH 43614 USA
[2] Med Coll Ohio, Dept Neurol Surg, Toledo, OH 43614 USA
[3] Univ Michigan, Dept Human Genet, Ann Arbor, MI 48109 USA
关键词
sodium channel; auditory; cartwheel cell; brain slice; transgenic mouse;
D O I
10.1016/S0006-8993(99)02031-4
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Spontaneous activity was recorded in the dorsal cochlear nucleus of brain slices from mice homozygous for the med-J and jolting mutations in the neuronal sodium channel alpha-subunit Scn8a. Densities of spontaneously active neurons in slices from both mutants were significantly lower than in control slices. Spontaneous firing patterns with bursts of action potentials were recorded from approximately 50% of the neurons in control slices, but the typical bursting patterns were not observed in neurons of med-J and jolting mouse slices. The results suggest that this voltage-gated sodium channel is essential for the spontaneous bursting firing of cochlear nucleus cartwheel neurons. This mutant animal model may be useful for the study of the functional roles of cochlear nucleus neurons. (C) 1999 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:85 / 89
页数:5
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