Growth factors in gliomas revisited

被引:43
作者
Hamel, W [1 ]
Westphal, M
机构
[1] Univ Kiel, Neurochirurg Klin, Kiel, Germany
[2] Univ Hamburg, Krankenhaus Eppendorf, Neurochirurg Klin, D-2000 Hamburg, Germany
关键词
glioma; growth factors; oncogenes; platelet-derived growth factor (PDGF); epidermal growth factor (EGF); erbB; vascular endothelial growth factor (VEGF); fibroblast growth factor (FGF); hepatocyte growth factor (HGF); insulin-like growth factor (IGF); therapy;
D O I
10.1007/s007010050015
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Overexpression or untimely expression of wild-type or mutated protein growth factors and their receptors is associated with the biology of malignant gliomas and other types of cancer. It may result in unchecked tumour cell proliferation, migration/invasion into normal tissue, tumour angiogenesis, escape from immune surveillance, and decreased apoptotic cell death, i.e. after treatment with cytotoxic agents. This often involves activation of growth factor receptors either by simultaneous production of growth factors and corresponding receptors on the same or adjacent tumour cells or by constitutive receptor activation due to mutations. In several instances, the cellular genes encoding these growth factors and receptors are homologous to transforming genes/oncogenes from tumourigenic retroviruses and have thus been regarded as cellular proto-oncogenes. In recent years much progress has been made towards a better understanding of the function of these molecules and how they lead to the aggressive phenotype of malignant gliomas and its inherent resistance to adjuvant therapies. This, still insufficient, knowledge is a prerequisite for the development of novel therapies for this non-curable disease. The aim of this review is to address relevant growth factor receptor systems with emphasis on their particular role in glioma biology.
引用
收藏
页码:113 / 138
页数:26
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