Acute immune polyneuropathies: Correlations of serum antibodies to Campylobacter jejuni and Helicobacter pylori with anti-GM(1) antibodies and clinical patterns of disease

被引:8
作者
Nevo, Y [1 ]
Pestronk, A [1 ]
机构
[1] WASHINGTON UNIV,SCH MED,DEPT NEUROL,ST LOUIS,MO 63110
关键词
D O I
10.1086/513784
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Antecedent Campylobacter jejuni infection, detected by serologic tests, has been implicated in some acute immune polyneuropathies (AIP). Antibodies to Helicobacter pylori, C. jejuni, and GM(1) ganglioside were measured in sera from 35 Chinese patients with AIP. Anti-GM(1) antibodies were found in 54% of C. jejuni-seropositive, H. pylori-seronegative patients. In contrast, anti-GM(1) antibodies were rare in sera that were either seropositive for bath C. jejuni and H, pylori (P = .04) or seronegative for C. jejuni (P = .01). Motor axonal AIP was more common in the C. jejuni seropositive, H. pylori-seronegative patients (82%) than in the bacterial antibody-negative group (38%). It was concluded that in AIP patients, C. jejuni-positive sera may be polyreactive, in that it may also react with H. pylori. In this situation, the specificity for either infection requires further validation. In contrast, sera with specific C. jejuni seropositivity are associated with both motor axonal AIP and selective serum IgG anti-GM(1) antibodies.
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页码:S154 / S156
页数:3
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