Rhone-Alpes observatory of Streptococcus pneumoniae in 1999:: 35 cases of meningitis

被引：3

作者：

Chomarat, M ^{[1
]}

Fredenucci, I ^{[1
]}

Barbé, G ^{[1
]}

Boucaud-Maitre, Y ^{[1
]}

Boyer, M ^{[1
]}

Carricajo, A ^{[1
]}

Célard, M ^{[1
]}

Clergeau, P ^{[1
]}

Croizé, J ^{[1
]}

Delubac, F ^{[1
]}

Fèvre, D ^{[1
]}

Fuhrmann, C ^{[1
]}

Gilles, Y ^{[1
]}

Gravagna, B ^{[1
]}

Helfre, M ^{[1
]}

Letouzey, MN ^{[1
]}

Lelièvre, H ^{[1
]}

Mandjee, A ^{[1
]}

Marchal, MF ^{[1
]}

Marthelet, P ^{[1
]}

Meley, R ^{[1
]}

Perrier-Gros-Claude, JD ^{[1
]}

Bercion, R ^{[1
]}

Reverdy, ME ^{[1
]}

Ros, A ^{[1
]}

Roure, C ^{[1
]}

Sabot, O ^{[1
]}

Smati, S ^{[1
]}

Thierry, J ^{[1
]}

Tixier, A ^{[1
]}

Tous, J ^{[1
]}

Verger, P ^{[1
]}

Zaoui, E ^{[1
]}

机构：

[1] CHU Lyon Sud, Microbiol Lab, F-69310 Pierre Benite, France

来源：

PATHOLOGIE BIOLOGIE | 2002年 / 50卷 / 10期

关键词：

meningitis; Rhone-Alpes; Streptococcus pneumoniae;

D O I：

10.1016/S0369-8114(02)00356-5

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

In 1999, in Rhone-Alpes region, in a survey of resistance to antibiotics of Streptococcus pneumoniae, 35 cases of meningitis were observed. A retrospectic questionnary was sent to each participant. MICs to Penicillin, Amoxicillin and Cefotaxime were determined with ATB-PNEUMO gallery or E-test and by disk diffusion for the other antibiotics. The results were interpreted according to the recommendations of the CA-SFM. Mean age was 38.1 years (range: 1 month -78 years) and sex-ratio 2/5. Eight patients had previously received antibiotics, 22 patients had risk factors and 23 were transfered in intensive care unit. The patients received C3G + glycopeptide in 15 of 16 children and in 13/19 adults according to the consensus recommendations. Diagnostic was made on the direct examination of CSF in 83%, and blood cultures was positive in 74.3% of cases. The percentage of PRP was 48.6% with 17.1% of intermediate-amoxicilline and 14.3% intermediate-cefotaxime strains. Resistance to trimethoprim-sulfamethoxazole was 45.7%, to chloramphenicol 30% and to fosfomycin 6.9%. All the strains were susceptible to rifampicin and vancomycin. Among the 17 PRP strains, 7 were belonging to serotype 6 (6 in children). The clinical outcome was fatal in 7 male cases (20%), without risk factors in 3 children and 6 of 7 strains were susceptible to penicillin. Six patients (17%) had auditive and/or neurologic sequellaes. This study shows that nearly 50% of strains isolated in meningitis, in Rhone-Alpes region, were not susceptible to penicillin, and confirms the frequency of sequellaes while the mortality is not related with the resistance of strains to the antibiotics. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.

引用

页码：595 / 598

页数：4

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