Requirement of Prorenin Receptor and Vacuolar H+-ATPase-Mediated Acidification for Wnt Signaling

被引：461

作者：

Cruciat, Cristina-Maria ^{[1
]}

Ohkawara, Bisei ^{[1
]}

Acebron, Sergio P. ^{[1
]}

Karaulanov, Emil ^{[1
]}

Reinhard, Carmen ^{[1
]}

Ingelfinger, Dierk ^{[2
,3
]}

Boutros, Michael ^{[2
,3
]}

Niehrs, Christof ^{[1
]}

机构：

[1] Deutsch Krebsforschungszentrum, DKFZ ZMBH Alliance, Div Mol Embryol, D-69120 Heidelberg, Germany

[2] Deutsch Krebsforschungszentrum, Div Signaling & Funct Genom, D-69120 Heidelberg, Germany

[3] Heidelberg Univ, D-69120 Heidelberg, Germany

来源：

SCIENCE | 2010年 / 327卷 / 5964期

关键词：

(PRO)RENIN RECEPTOR; ACTIVATION; PROTEIN; LRP6; IDENTIFICATION; MEMBRANE; PATHWAY; COMPLEX; KINASE; GENES;

D O I：

10.1126/science.1179802

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Wnt/beta-catenin signaling is important in stem cell biology, embryonic development, and disease, including cancer. However, the mechanism of Wnt signal transmission, notably how the receptors are activated, remains incompletely understood. We found that the prorenin receptor (PRR) is a component of the Wnt receptor complex. PRR functions in a renin-independent manner as an adaptor between Wnt receptors and the vacuolar H+-adenosine triphosphatase (V-ATPase) complex. Moreover, PRR and V-ATPase were required to mediate Wnt signaling during antero-posterior patterning of Xenopus early central nervous system development. The results reveal an unsuspected role for the prorenin receptor, V-ATPase activity, and acidification during Wnt/beta-catenin signaling.

引用

页码：459 / 463

页数：5

共 31 条

[1] Identification of 315 genes essential for early zebrafish development
Amsterdam, A
Nissen, RM
Sun, ZX
Swindell, EC
Farrington, S
Hopkins, N
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (35) : 12792 - 12797
[2] The V-type H+ ATPase:: molecular structure and function, physiological roles and regulation
Beyenbach, KW
Wieczorek, H
[J]. JOURNAL OF EXPERIMENTAL BIOLOGY, 2006, 209 (04) : 577 - 589
[3] Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation
Bilic, Josipa
Huang, Ya-Lin
Davidson, Gary
Zimmermann, Timo
Cruciat, Cristina-Maria
Bienz, Mariann
Niehrs, Christof
[J]. SCIENCE, 2007, 316 (5831) : 1619 - 1622
[4] A critical role for endocytosis in Wnt signaling
Blitzer, Jeremy T.
Nusse, Roel
[J]. BMC CELL BIOLOGY, 2006, 7 (1)
[5] Critical review of prorenin and (pro)renin receptor research
Campbell, Duncan J.
[J]. HYPERTENSION, 2008, 51 (05) : 1259 - 1264
[6] Wnt/β-catenin signaling in development and disease
Clevers, Hans
[J]. CELL, 2006, 127 (03) : 469 - 480
[7] A role of the (pro)renin receptor in neuronal cell differentiation
Contrepas, Aurelie
Walker, Joy
Koulakoff, Annette
Franek, Karl J.
Qadri, Fatimunnisa
Giaume, Christian
Corvol, Pierre
Schwartz, Charles E.
Nguyen, Genevieve
[J]. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2009, 297 (02) : R250 - R257
[8] Casein kinase 1γ couples Wnt receptor activation to cytoplasmic signal transduction
Davidson, G
Wu, W
Shen, JL
Bilic, J
Fenger, U
Stannek, P
Glinka, A
Niehrs, C
[J]. NATURE, 2005, 438 (7069) : 867 - 872
[9] Vacuolar ATPases: rotary proton pumps in physiology and pathophysiology
Forgac, Michoel
[J]. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2007, 8 (11) : 917 - 929
[10] The vacuolar-ATPase inhibitor bafilomycin and mutant VPS35 inhibit canonical Wnt signaling
George, Ana
Leahy, Hannah
Zhou, Jianhua
Morin, Peter J.
[J]. NEUROBIOLOGY OF DISEASE, 2007, 26 (01) : 125 - 133

← 1 2 3 4 →