Porphyrin derivatives:: Synthesis and potential applications

被引:26
作者
Cavaleiro, JAS [1 ]
Neves, MGPM [1 ]
Tomé, AC [1 ]
Silva, AMS [1 ]
Faustino, MAF [1 ]
Lacerda, PS [1 ]
Silva, AMG [1 ]
机构
[1] Univ Aveiro, Dept Chem, P-3810193 Aveiro, Portugal
关键词
D O I
10.1002/jhet.5570370310
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Porphyrin-porphyrin and porphyrin-chlorin dimers have been synthesized and evaluated for their photo-physical and in vivo photodynamic therapy properties. Two of them can become potential new photosensitizers. Study of the reactivity of meso-tetraaryl porphyrins, as dienophiles, in Diels-Alder transformations and as dipolarophiles in 1,3-dipolar cycloadditions, has been undertaken. New synthetic methodologies for certain chlorin, bacteriochlorin and isobacteriochlorin type macrocycles, with potential biological significance, have been established.
引用
收藏
页码:527 / 534
页数:8
相关论文
共 18 条
[2]  
BONNETT R, 1998, PHOTODYNAMIC TUMOR T
[3]  
BONNETT R, 1992, PHOTODYNAMIC THERAPY
[4]   DIELS-ALDER REACTIONS OF PROTOPORPHYRIN DIMETHYL ESTERS WITH NITROSOBENZENES - A NOVEL DEGRADATION TO FORMYL PORPHYRINS [J].
CAVALEIRO, JAS ;
JACKSON, AH ;
NEVES, MGPMS ;
RAO, KRN .
JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1985, (12) :776-777
[5]   REACTIONS OF PROTOPORPHYRIN WITH TETRACYANOETHYLENE [J].
DINELLO, RK ;
DOLPHIN, D .
JOURNAL OF ORGANIC CHEMISTRY, 1980, 45 (25) :5196-5204
[6]   Porphyrin-modified electrodes as biomimetic sensors for the determination of organohalide pollutants in aqueous samples [J].
Dobson, DJ ;
Saini, S .
ANALYTICAL CHEMISTRY, 1997, 69 (17) :3532-3538
[7]   Meso-tetraphenylporphyrin dimer derivative as a potential photosensitizer in photodynamic therapy [J].
Faustino, MAF ;
Neves, MGPMS ;
Vicente, MGH ;
Cavaleiro, JAS ;
Neumann, M ;
Brauer, HD ;
Jori, G .
PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1997, 66 (04) :405-412
[8]   Diels-Alder reactions of Ni(II) beta-vinyl-meso-tetraarylporphyrins [J].
Faustino, MAF ;
Neves, MGPMS ;
Vicente, MGH ;
Silva, AMS ;
Cavaleiro, JAS .
TETRAHEDRON LETTERS, 1996, 37 (20) :3569-3570
[9]  
FAUSTINO MAF, 1997, CHIMIA, V7, P472
[10]  
FAUSTINO MAF, IN PRESS PHOTOCHEM P