A Wolbachia Symbiont in Aedes aegypti Limits Infection with Dengue, Chikungunya, and Plasmodium

被引：1231

作者：

Moreira, Luciano A. ^{[1
,2
]}

Iturbe-Ormaetxe, Inaki ^{[1
]}

Jeffery, Jason A. ^{[3
]}

Lu, Guangjin ^{[3
]}

Pyke, Alyssa T. ^{[4
,5
]}

Hedges, Lauren M. ^{[1
]}

Rocha, Bruno C. ^{[2
]}

Hall-Mendelin, Sonja ^{[6
]}

Day, Andrew ^{[6
]}

Riegler, Markus ^{[1
]}

Hugo, Leon E. ^{[3
]}

Johnson, Karyn N. ^{[1
]}

Kay, Brian H. ^{[3
]}

McGraw, Elizabeth A. ^{[1
]}

van den Hurk, Andrew F. ^{[4
,5
,6
]}

Ryan, Peter A. ^{[3
]}

O'Neill, Scott L. ^{[1
]}

机构：

[1] Univ Queensland, Sch Biol Sci, Brisbane, Qld 4072, Australia

[2] Fiocruz MS, Rene Rachou Res Inst, Belo Horizonte, MG, Brazil

[3] Queensland Inst Med Res, Brisbane, Qld 4029, Australia

[4] Queensland Hlth Forens Serv, Coopers Plains, Qld 4108, Australia

[5] Queensland Hlth Sci Serv, Coopers Plains, Qld 4108, Australia

[6] Univ Queensland, Sch Chem & Mol Biosci, Brisbane, Qld 4072, Australia

来源：

CELL | 2009年 / 139卷 / 07期

基金：

美国国家卫生研究院; 英国医学研究理事会;

关键词：

MONOCLONAL-ANTIBODIES; STATISTICAL-ANALYSIS; VIRULENT WOLBACHIA; MOSQUITO; CHOLESTEROL; EXPRESSION; DROSOPHILA; PROTEIN; FEVER; PCR;

D O I：

10.1016/j.cell.2009.11.042

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Wolbachia are maternally inherited intracellular bacterial symbionts that are estimated to infect more than 60% of all insect species. While Wolbachia is commonly found in many mosquitoes it is absent from the species that are considered to be of major importance for the transmission of human pathogens. The successful introduction of a life-shortening strain of Wolbachia into the dengue vector Aedes aegypti that halves adult lifespan has recently been reported. Here we show that this same Wolbachia infection also directly inhibits the ability of a range of pathogens to infect this mosquito species. The effect is Wolbachia strain specific and relates to Wolbachia priming of the mosquito innate immune system and potentially competition for limiting cellular resources required for pathogen replication. We suggest that this Wolbachia-mediated pathogen interference may work synergistically with the life-shortening strategy proposed previously to provide a powerful approach for the control of insect transmitted diseases.

引用

页码：1268 / 1278

页数：11

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