Widespread functional connectivity and fMR1 fluctuations in human visual cortex in the absence of visual stimulation

被引:162
作者
Nir, Yuval
Hasson, Uri
Levy, Ifat
Yeshurun, Yehezkel
Malach, Rafael [1 ]
机构
[1] Weizmann Inst Sci, Dept Neurobiol, IL-76100 Rehovot, Israel
[2] NYU, Ctr Neural Sci, New York, NY 10003 USA
[3] Tel Aviv Univ, Sch Comp Sci, IL-61390 Tel Aviv, Israel
关键词
spontaneous activity; ongoing activity; rest activity; decoherence; functional connectivity;
D O I
10.1016/j.neuroimage.2005.11.018
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
To what extent does the visual system's activity fluctuate when no sensory stimulation is present? Here, we studied this issue by examining spontaneous fluctuations in BOLD signal in the human visual system, while subjects were placed in complete darkness. Our results reveal widespread slow fluctuations during such rest periods. In contrast to stimulus-driven activity, during darkness, functionally distinct object areas were fluctuating in unison. These fMRI fluctuations became rapidly spatially de-correlated (39% drop in correlation level, P < 0.008) during visual stimulation. Functional connectivity analysis revealed that the slow spontaneous fluctuations during rest had consistent and specific neuro-anatomical distribution which argued against purely hemodynamic noise sources. Control experiments ruled out eye closure, low luminance and mental imagery as the underlying sources of the spontaneous fluctuations. These results demonstrate that, when no stimulus is present, sensory systems manifest a robust level of slow organized fluctuation patterns. (c) 2005 Elsevier Inc. All rights reserved.
引用
收藏
页码:1313 / 1324
页数:12
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