Cell surface receptor directed targeting of toxin to human malaria parasite, Plasmodium falciparum

被引：16

作者：

Surolia, N ^{[1
]}

Misquith, S ^{[1
]}

机构：

[1] ST JOSEPHS COLL,DEPT CHEM,BANGALORE,KARNATAKA,INDIA

来源：

FEBS LETTERS | 1996年 / 396卷 / 01期

关键词：

Plasmodium falciparum; toxin; ribosome inactivating protein; Gelonin-transferrin conjugate; targeting;

D O I：

10.1016/0014-5793(96)01065-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Gelonin (a toxin and type II ribosome inactivating protein) when linked to human transferrin can be targeted to Plasmodium falciparum. The transferrin toxin conjugate is significantly toxic to parasite growth and is 25 times more potent than toxin alone in inhibiting parasite protein synthesis. The mechanism of its entry into the intraerythrocytic parasite is discussed.

引用

页码：57 / 61

页数：5

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