Association between seropositivity to Chlamydia pneumoniae and acute ischaemic stroke

被引：36

作者：

Madre, JG

Garcia, JLR ^{[1
]}

Gonzalez, RC

Montero, JM

Paniagua, EB

Escribano, JRG

Martinez, JD

Cenjor, RF

机构：

[1] Hosp Mancha Ctr, Med Interna Serv, Alcazar De San Juan 13600, Spain

[2] Hosp Mancha Ctr, Microbiol Serv, Alcazar De San Juan 13600, Spain

来源：

EUROPEAN JOURNAL OF NEUROLOGY | 2002年 / 9卷 / 03期

关键词：

acute ischaemic stroke; cerebrovascular disease; Chlamydia pneumoniae;

D O I：

10.1046/j.1468-1331.2002.00408.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Recent studies suggest an association between Chlamydia pneumoniae infection with atherosclerosis, including cerebrovascular disease. We investigated the prevalence of Chlamydial seropositivity in patients with acute ischaemic stroke syndrome compared with age- and sex-matched control subjects. Specific antibodies (IgA) to C. pneumoniae were measured by microimmunofluorescence in both the clinical group (n=91)and the control group (n=112). Forty patients (43.9%) and 34 controls (30.3%) had positive IgA titres (P<0.05). The pooled data from this and previous series yielded 45% of seropositivity in cerebrovascular patients vs. 19% in control subjects (P<0.001). In conclusion, we suggest an association between chronic infection by C. pneumoniae and acute ischaemic stroke.

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页码：303 / 306

页数：4

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