Multiplicity of mechanisms of serotonin receptor signal transduction

被引：363

作者：

Raymond, JR

Mukhin, YV

Gelasco, A

Turner, J

Collinsworth, G

Gettys, TW

Grewal, JS

Garnovskaya, MN

机构：

[1] Med Univ S Carolina, Dept Med, Div Nephrol, Charleston, SC 29425 USA

[2] Ralph H Johnson Vet Affairs Med Ctr, Res Serv, Charleston, SC 29401 USA

[3] Med Univ S Carolina, Dept Med, Div Gastroenterol, Charleston, SC 29425 USA

[4] Med Univ S Carolina, Dept Biochem, Charleston, SC 29425 USA

[5] Med Univ S Carolina, Dept Biol Mol, Charleston, SC 29425 USA

来源：

PHARMACOLOGY & THERAPEUTICS | 2001年 / 92卷 / 2-3期

关键词：

signal transduction; adenylyl cyclase; phospholipase; kinase; channel;

D O I：

10.1016/S0163-7258(01)00169-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The serotonin (5-hydroxytryptamine, 5-HT) receptors have been divided into 7 subfamilies by convention, 6 of which include 13 different genes for G-protein-coupled receptors. Those subfamilies have been characterized by overlapping pharmacological properties, amino acid sequences, gene organization, and second messenger coupling pathways. Post-genomic modifications, such as alternative mRNA splicing or mRNA editing, creates at least 20 more G-protein-coupled 5-HT receptors, such that there are at least 30 distinct 5-HT receptors that signal through G-proteins, This review will focus on what is known about the signaling linkages of the G-protein-linked 5-HT receptors, and will highlight some fascinating new insights into 5-HT receptor signaling. (C) 2001 Elsevier Science Inc. All rights reserved.

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页码：179 / 212

页数：34

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