We have measured the O-isotope effects on the magnetic and electrical propel-ties of La0.65Ca0.35MnO3 under hydrostatic pressure up to 1.9 GPa. The pressure was found to reversibly enhance the metal-insulator transition temperature T-C and suppress the resistivity rho of both isotopic samples, but at different rates, depending on the O-isotopic mass of the samples. It was also found that pressure suppresses the isotope effect linearly, while the O-18-->O-16 exchanee drastically enhances rho. The greater d In T-C/dP and \d In rho/dP\ observed in the O-18 sample can he understood qualitatively in terms of the double exchange interaction between Mn ions and the band reduction effect of polarons, but the d In T-C/dP difference is much greater than predicted. The discrepancy suggests that modifications may be needed for the model. [S0163-1829(99)50146-X].