Cloning and distribution of the rat parkin mRNA

被引：32

作者：

D'Agata, V

Zhao, WQ

Cavallaro, S

机构：

[1] Italian Res Council, Inst Bioimaging & Pathophysiol Cent Nervous Syst, I-95123 Catania, Italy

[2] IRCCS, Oasi Inst Res Mental Retardat & Brain Aging, Troina, EN, Italy

[3] NINDS, Lab Adaptive Syst, NIH, Bethesda, MD 20892 USA

来源：

MOLECULAR BRAIN RESEARCH | 2000年 / 75卷 / 02期

关键词：

autosomal recessive juvenile parkinsonism; parkin; rat; distribution;

D O I：

10.1016/S0169-328X(99)00286-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We have isolated by RT-PCR and sequenced a partial cDNA coding for the rat homolog of parkin, a gene mutated in autosomal recessive juvenile parkinsonism. The 1.46 kb rat cDNA clone contains a 1376 bp coding sequence that shares strong similarity with the human parkin cDNA. RT-PCR and in situ hybridization revealed widespread expression of parkin in the rat brain and the periphery. The availability of the rat parkin cDNA and the initial elucidation of its distribution should facilitate further research on the pathophysiological role of parkin in the nervous system. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：345 / 349

页数：5

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