Phospholipase C and termination of G-protein-mediated signalling in vivo

被引：78

作者：

Cook, B

Bar-Yaacov, M

Ben-Ami, HC

Goldstein, RE

Paroush, Z

Selinger, Z

Minke, B ^{[1
]}

机构：

[1] Hebrew Univ Jerusalem, Dept Physiol, IL-91120 Jerusalem, Israel

[2] Hebrew Univ Jerusalem, Kuhne Minerva Ctr Studies Visual Transduct, IL-91120 Jerusalem, Israel

[3] Hebrew Univ Jerusalem, Dept Biol Chem, IL-91904 Jerusalem, Israel

[4] Hebrew Univ Jerusalem, Kuhne Minerva Ctr Studies Visual Transduct, IL-91904 Jerusalem, Israel

[5] Hebrew Univ Jerusalem, Dept Biochem, IL-91120 Jerusalem, Israel

[6] Hebrew Univ Jerusalem, Kuhne Minerva Ctr Studies Visual Transduct, IL-91120 Jerusalem, Israel

来源：

NATURE CELL BIOLOGY | 2000年 / 2卷 / 05期

关键词：

D O I：

10.1038/35010571

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In Drosophila photoreceptors, phospholipase C (PLC) and other signalling components form multiprotein structures through the PDZ scaffold protein INAD. Association between PLC and INAD is important for termination of responses to light; the underlying mechanism is, however, unclear. Here we report that the maintenance of large amounts of PLC in the signalling membranes by association with INAD facilitates response termination, and show that PLC functions as a GTPase-activating protein (GAP). The inactivation of the G protein by its target, the PLC, is crucial for reliable production of single-photon responses and for the high temporal and intensity resolution of the response to light.

引用

页码：296 / 301

页数：6

共 44 条

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