Photo-triggered selective C-terminal N-methylamidative cleavage of polyethyleneglycol-bound peptides

被引：4

作者：

Ajayaghosh, A ^{[1
]}

Pillai, VNR ^{[1
]}

机构：

[1] MAHATMA GANDHI UNIV,SCH CHEM SCI,KOTTAYAM 686560,KERALA,INDIA

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 35期

关键词：

D O I：

10.1016/0040-4039(96)01363-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A navel liquid-phase method has been designed for the photolytic release of the attached peptides, directly as their C-terminal N-methylamides, under mild conditions in excellent yields and purity. The present approach provides fully side-chain protected peptide N-methylamides, useful for segment condensation and facilitate photo-controlled release of biologically active peptides for therapeutic applications. Copyright (C) 1996 Published by Elsevier Science Ltd

引用

页码：6421 / 6424

页数：4

共 15 条

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