Molecular pathology of allergic disease - I: Lower airway disease

被引：68

作者：

Hamid, QA ^{[1
]}

Minshall, EM ^{[1
]}

机构：

[1] McGill Univ, Meakins Christie Labs, Montreal, PQ H2X 2P2, Canada

来源：

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 2000年 / 105卷 / 01期

关键词：

bronchial asthma; eosinophils; T lymphocytes; cytokines; chemokines;

D O I：

10.1016/S0091-6749(00)90172-6

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Asthma is a complex disorder associated with eosinophil infiltration and the activation of T lymphocytes within the airways, Recent advances in the pathophysiologic mechanisms of asthma point to the importance of eosinophil-basophil progenitor cells and a family of transcription factors that underlie the development of T-H(2)-type responses. Further research is needed to address the development of chronic inflammatory changes, the role of profibrotic cytokines, and especially their reliance on eosinophils in the lungs.

引用

页码：20 / 36

页数：17

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