MERS-CoV spike nanoparticles protect mice from MERS-CoV infection

被引：77

作者：

Coleman, Christopher M. ^{[1
]}

Venkataraman, Thiagarajan ^{[1
]}

Liu, Ye V. ^{[2
]}

Glenn, Gregory M. ^{[2
]}

Smith, Gale E. ^{[2
]}

Flyer, David C. ^{[2
]}

Frieman, Matthew B. ^{[1
]}

机构：

[1] Univ Maryland, Sch Med, 685 West Baltimore St, Baltimore, MD 21201 USA

[2] Novavax Inc, 22 Firstfield Rd, Rockville, MD 20852 USA

来源：

VACCINE | 2017年 / 35卷 / 12期

关键词：

MERS-CoV; Nanoparticle vaccine; Mouse model; Coronavirus; DIPEPTIDYL PEPTIDASE 4; FUNCTIONAL RECEPTOR; CORONAVIRUS; ANTIBODY;

D O I：

10.1016/j.vaccine.2017.02.012

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

The Middle East respiratory syndrome coronavirus (MERS-CoV) was first discovered in late 2012 and has gone on to cause over 1800 infections and 650 deaths. There are currently no approved therapeutics or vaccinations for MERS-CoV. The MERS-CoV spike (S) protein is responsible for receptor binding and virion entry to cells, is immunodominant and induces neutralizing antibodies in vivo, all of which, make the S protein an ideal target for anti-MERS-CoV vaccines. In this study, we demonstrate protection induced by vaccination with a recombinant MERS-CoV S nanoparticle vaccine and Matrix-M1 adjuvant combination in mice. The MERS-CoV S nanoparticle vaccine produced high titer anti-S neutralizing antibody and protected mice from MERS-CoV infection in vivo. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：1586 / 1589

页数：4

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