Calcimimetics: therapeutic potential in hyperparathyroidism

被引：19

作者：

Cohen, A ^{[1
]}

Silverberg, SJ ^{[1
]}

机构：

[1] Columbia Presbyterian Med Ctr, Div Endocrinol, New York, NY 10032 USA

来源：

CURRENT OPINION IN PHARMACOLOGY | 2002年 / 2卷 / 06期

关键词：

D O I：

10.1016/S1471-4892(02)00210-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Calcium homeostasis is essential for the normal function of many organ systems. The recently cloned extracellular calcium-sensing receptor plays a central role in this process and thus represents an important target for therapeutic agents aimed at treating disorders of calcium metabolism. Compounds, such as the phenylalkylamines NPS 568 and AMG 073, act as agonists of calcium at this receptor. These calcimimetic agents hold promise as potential treatments for diseases of parathyroid hyperfunction, such as primary and secondary hyperparathyroidism.

引用

页码：734 / 739

页数：6

共 42 条

[1]

AKIZAWA T, 1998, AM J SOC NEPHROL, V9, pA561

[2] A calcimimetic agent acutely suppresses parathyroid hormone levels in patients with chronic renal failure -: Rapid communication [J].

Antonsen, JE ;

Sherrard, DJ ;

Andress, DL .

KIDNEY INTERNATIONAL, 1998, 53 (01) :223-227

[3] URINARY CALCIUM EXCRETION IN FAMILIAL HYPOCALCIURIC - PERSISTENCE OF RELATIVE HYPOCALCIURIA AFTER INDUCTION OF HYPOPARATHYROIDISM [J].

ATTIE, MF ;

GILL, JR ;

STOCK, JL ;

SPIEGEL, AM ;

DOWNS, RW ;

LEVINE, MA ;

MARX, SJ .

JOURNAL OF CLINICAL INVESTIGATION, 1983, 72 (02) :667-676

[4] Mutations in the Ca2+-sensing receptor gene cause autosomal dominant and sporadic hypoparathyroidism [J].

Baron, J ;

Winer, KK ;

Yanovski, JA ;

Cunningham, AW ;

Laue, L ;

Zimmerman, D ;

Cutler, GB .

HUMAN MOLECULAR GENETICS, 1996, 5 (05) :601-606

[5] SEMINARS IN MEDICINE OF THE BETH-ISRAEL-HOSPITAL, BOSTON - CALCIUM-ION-SENSING CELL-SURFACE RECEPTORS [J].

BROWN, EM ;

POLLAK, M ;

SEIDMAN, CE ;

SEIDMAN, JG ;

RICCARDI, D ;

HEBERT, SC .

NEW ENGLAND JOURNAL OF MEDICINE, 1995, 333 (04) :234-240

[6] CLONING AND CHARACTERIZATION OF AN EXTRACELLULAR CA2+-SENSING RECEPTOR FROM BOVINE PARATHYROID [J].

BROWN, EM ;

GAMBA, G ;

RICCARDI, D ;

LOMBARDI, M ;

BUTTERS, R ;

KIFOR, O ;

SUN, A ;

HEDIGER, MA ;

LYTTON, J ;

HEBERT, SC .

NATURE, 1993, 366 (6455) :575-580

[7] Physiology and pathophysiology of the extracellular calcium-sensing receptor [J].

Brown, EM .

AMERICAN JOURNAL OF MEDICINE, 1999, 106 (02) :238-253

[8] Mutations in the calcium-sensing receptor and their clinical implications [J].

Brown, EM .

HORMONE RESEARCH, 1997, 48 (05) :199-208

[9] Biochemistry, physiology and pathophysiology of the extracellular calcium-sensing receptor [J].

Chattopadhyay, N .

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2000, 32 (08) :789-804

[10]

Chin J, 2000, J AM SOC NEPHROL, V11, P903, DOI 10.1681/ASN.V115903

← 1 2 3 4 5 →