Diagnosis, epidemiology, and genetics of the polycystic ovary syndrome

被引：131

作者：

Goodarzi, Mark O.

Azziz, Ricardo

机构：

[1] Cedars Sinai Med Ctr, Dept Obstet & Gynecol, Ctr Androgen Related Disorders, Los Angeles, CA 90048 USA

[2] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA USA

[3] Inst Med Genet, Dept Med, Div Endocrinol Diabet & Metab, Los Angeles, CA USA

来源：

BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM | 2006年 / 20卷 / 02期

关键词：

epidemiology; polycystic ovary syndrome; phenotyping; complex disorders;

D O I：

10.1016/j.beem.2006.02.005

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Polycystic ovary syndrome (PCOS) is a heterogeneous disorder, and its definition remains fluid and controversial. PCOS is characterized by clinical and/or biochemical hyperandrogenism, and is frequently accompanied by ovulatory dysfunction and polycystic ovaries. PCOS is a diagnosis of exclusion, with other androgen excess and related disorders to be excluded. The prevalence of PCOS is 6.5-8.0% of unselected women of reproductive age, using the NIH 1990 criteria. Genetically, PCOS is a common, complex disorder. Despite repeated attempts to identify the putative gene or genes responsible for this disorder, the PCOS gene(s) remain elusive.

引用

页码：193 / 205

页数：13

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