Mitochondrial biogenesis and dynamics in the developing and diseased heart

被引：502

作者：

Dorn, Gerald W., II ^{[1
]}

Vega, Rick B. ^{[2
]}

Kelly, Daniel P. ^{[2
]}

机构：

[1] Washington Univ, Ctr Pharmacogenom, St Louis, MO 63110 USA

[2] Sanford Burnham Prebys Med Discovery Inst, Cardiovasc Metab Program, Orlando, FL 32827 USA

来源：

GENES & DEVELOPMENT | 2015年 / 29卷 / 19期

基金：

美国国家卫生研究院;

关键词：

mitochondria; biogenesis; mitophagy; mitochondrial dynamics; PROLIFERATOR-ACTIVATED RECEPTOR; FATTY-ACID OXIDATION; PALMITOYLTRANSFERASE I GENE; NUCLEAR RESPIRATORY FACTORS; ALPHA PPAR-ALPHA; SKELETAL-MUSCLE; ERR-ALPHA; MICE LACKING; PERIIMPLANTATION LETHALITY; GAMMA COACTIVATOR-1-ALPHA;

D O I：

10.1101/gad.269894.115

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

The mitochondrion is a complex organelle that serves essential roles in energy transduction, ATP production, and a myriad of cellular signaling events. A finely tuned regulatory network orchestrates the biogenesis, maintenance, and turnover of mitochondria. The high-capacity mitochondrial system in the heart is regulated in a dynamic way to generate and consume enormous amounts of ATP in order to support the constant pumping function in the context of changing energy demands. This review describes the regulatory circuitry and downstream events involved in mitochondrial biogenesis and its coordination with mitochondrial dynamics in developing and diseased hearts.

引用

页码：1981 / 1991

页数：11

共 105 条

[1]

Myc controls transcriptional regulation of cardiac metabolism and mitochondrial biogenesis in response to pathological stress in mice [J].

Ahuja, Preeti ;

Zhao, Peng ;

Angelis, Ekaterini ;

Ruan, Hongmei ;

Korge, Paavo ;

Olson, Aaron ;

Wang, Yibin ;

Jin, Eunsook S. ;

Jeffrey, F. Mark ;

Portman, Michael ;

MacLellan, W. Robb .

JOURNAL OF CLINICAL INVESTIGATION, 2010, 120 (05) :1494-1505

[2]

Exercise stimulates Pgc-1α transcription in skeletal muscle through activation of the p38 MAPK pathway [J].

Akimoto, T ;

Pohnert, SC ;

Li, P ;

Zhang, M ;

Gumbs, C ;

Rosenberg, PB ;

Williams, RS ;

Yan, Z .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (20) :19587-19593

[3]

Compensated cardiac hypertrophy is characterised by a decline in palmitate oxidation [J].

Akki, Ashwin ;

Smith, Katie ;

Seymour, Anne-Marie L. .

MOLECULAR AND CELLULAR BIOCHEMISTRY, 2008, 311 (1-2) :215-224

[4]

ERRγ directs and maintains the transition to oxidative metabolism in the postnatal heart [J].

Alaynick, William A. ;

Kondo, Richard P. ;

Xie, Wen ;

He, Weimin ;

Dufour, Catherine R. ;

Downes, Michael ;

Jonker, Johan W. ;

Giles, Wayne ;

Naviaux, Robert K. ;

Giguere, Vincent ;

Evans, Ronald M. .

CELL METABOLISM, 2007, 6 (01) :13-24

[5]

Andersson, U ;

Scarpulla, RC .

MOLECULAR AND CELLULAR BIOLOGY, 2001, 21 (11) :3738-3749

[6]

Altered constitutive expression of fatty acid-metabolizing enzymes in mice lacking the peroxisome proliferator-activated receptor α (PPARα) [J].

Aoyama, T ;

Peters, JM ;

Iritani, N ;

Nakajima, T ;

Furihata, K ;

Hashimoto, T ;

Gonzalez, FJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (10) :5678-5684

[7]

Transverse aortic constriction leads to accelerated heart failure in mice lacking PPAR-γ coactivator 1α [J].

Arany, Zoltan ;

Novikov, Mikhail ;

Chin, Sherry ;

Ma, Yanhong ;

Rosenzweig, Anthony ;

Spiegelman, Bruce M. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (26) :10086-10091

[8]

Metabolic mechanisms in heart failure [J].

Ashrafian, Houman ;

Frenneaux, Michael P. ;

Opie, Lionel H. .

CIRCULATION, 2007, 116 (04) :434-448

[9]

Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC-1 [J].

Baar, K ;

Wende, AR ;

Jones, TE ;

Marison, M ;

Nolte, LA ;

Chen, M ;

Kelly, DP ;

Holloszy, JO .

FASEB JOURNAL, 2002, 16 (14) :1879-1886

[10]

REGULATION OF OXIDATIVE-PHOSPHORYLATION IN THE MAMMALIAN-CELL [J].

BALABAN, RS .

AMERICAN JOURNAL OF PHYSIOLOGY, 1990, 258 (03) :C377-C389

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