New Fmoc pseudoisocytosine monomer for the synthesis of a bis-PNA molecule by automated solid-phase Fmoc chemistry

被引：11

作者：

Neuner, P ^{[1
]}

Monaci, P ^{[1
]}

机构：

[1] Ist Ric Biol Mol P Angeletti, I-00040 Rome, Italy

来源：

BIOCONJUGATE CHEMISTRY | 2002年 / 13卷 / 03期

关键词：

D O I：

10.1021/bc0100758

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The synthesis of N-[2-(N-9-fluorenylmethoxycarbonyl)aminoethyll-N-(2-N-(benzyloxycarbonyl)isocytosin-5-ylacetyl)glycine monomer and its incorporation into a PNA molecule via automated Fmoc solid-phase chemistry is described.

引用

页码：676 / 678

页数：3

共 8 条

[1]

COULL JM, Patent No. 9640685

[2] SYNTHESIS OF PEPTIDE NUCLEIC-ACID MONOMERS CONTAINING THE 4 NATURAL NUCLEOBASES - THYMINE, CYTOSINE, ADENINE, AND GUANINE AND THEIR OLIGOMERIZATION [J].

DUEHOLM, KL ;

EGHOLM, M ;

BEHRENS, C ;

CHRISTENSEN, L ;

HANSEN, HF ;

VULPIUS, T ;

PETERSEN, KH ;

BERG, RH ;

NIELSEN, PE ;

BUCHARDT, O .

JOURNAL OF ORGANIC CHEMISTRY, 1994, 59 (19) :5767-5773

[3] EFFICIENT PH-INDEPENDENT SEQUENCE-SPECIFIC DNA-BINDING BY PSEUDOISOCYTOSINE-CONTAINING BIS-PNA [J].

EGHOLM, M ;

CHRISTENSEN, L ;

DUEHOLM, KL ;

BUCHARDT, O ;

COULL, J ;

NIELSEN, PE .

NUCLEIC ACIDS RESEARCH, 1995, 23 (02) :217-222

[4]

HUHN H, 1999, J MOL BIOL, V286, P1337

[5]

KNUDSEN H, 1996, NUCLEIC ACIDS RES, V24, P495

[6] Automated synthesis of peptide nucleic acids and peptide nucleic acid peptide conjugates [J].

Mayfield, LD ;

Corey, DR .

ANALYTICAL BIOCHEMISTRY, 1999, 268 (02) :401-404

[7] SEQUENCE-SELECTIVE RECOGNITION OF DNA BY STRAND DISPLACEMENT WITH A THYMINE-SUBSTITUTED POLYAMIDE [J].

NIELSEN, PE ;

EGHOLM, M ;

BERG, RH ;

BUCHARDT, O .

SCIENCE, 1991, 254 (5037) :1497-1500

[8]

Thompson S. A., 1995, TETRAHEDRON, V22, P6179

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