Animal model pharmacokinetics and pharmacodynamics: a critical review

被引：314

作者：

Andes, D ^{[1
]}

Craig, WA ^{[1
]}

机构：

[1] Univ Wisconsin, Madison, WI 53706 USA

来源：

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | 2002年 / 19卷 / 04期

关键词：

pharmacokinetic/pharmacodynamic; antimicrobials; pathogens;

D O I：

10.1016/S0924-8579(02)00022-5

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Animals have been extensively used in the evaluation of antimicrobials. The value of animals in the pharmacokinetic and pharmacodynamic characterization of antimicrobials is critically reviewed. Animal studies have demonstrated that the pharmacokinetic/pharmacodynamic (PK/PD) target determining efficacy can vary for different classes of antimicrobials. However, the magnitude of the target required for bacteriological efficacy is relatively similar for various sites of infection, various pathogens and various drugs within the same class, provided free drug levels are used. (C) 2002 Elsevier Science B.V. and International Society of Chemotherapy. All rights reserved.

引用

页码：261 / 268

页数：8

共 21 条

[1] In vivo activities of amoxicillin and amoxicillin-clavulanate against Streptococcus pneumoniae:: Application to breakpoint determinations [J].