Innovative vaccine production technologies: The evolution and value of vaccine production technologies

被引：14

作者：

Bae, KyungDong ^{[1
]}

Choi, JunYoul ^{[1
]}

Jang, YangSuk ^{[1
]}

Ahn, SangJeom ^{[1
]}

Hur, ByungKi ^{[2
]}

机构：

[1] CrucellBerna Biotech Korea, Vaccine Res Inst, Yongin 449903, South Korea

[2] Inha Univ, Dept Biotechnol & Bioengn, Inchon 402751, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2009年 / 32卷 / 04期

关键词：

Vaccine; Antigen; Adjuvant; CpG; Virosome; Ty21a; ACELLULAR PERTUSSIS VACCINES; HEPATITIS-B-VACCINE; INFLUENZA-VIRUS VACCINE; VI CAPSULAR POLYSACCHARIDE; ADP-RIBOSYLATION ACTIVITY; HUMAN ROTAVIRUS VACCINE; WHOLE-CELL PERTUSSIS; TYPHOID-FEVER; SALMONELLA-TYPHI; COMBINATION VACCINES;

D O I：

10.1007/s12272-009-1400-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

This review paper provides an overview of innovative technologies designed to produce bacterial, viral, recombinant subunit, and polysaccharide vaccines, as well as combination vaccines. Advances in this field are illustrated by vaccines against DTP (diphtheria-tetanus-pertussis), influenza, hepatitis B (HepB) and typhoid fever. In addition, technological trends regarding antigens, adjuvants, and preservatives in vaccines are discussed. The progress achieved in vaccine production technologies is especially important for improving the protection of vulnerable populations against infectious diseases. These at-risk groups include infants, the elderly and immunocompromized individuals, as well as people living in developing countries or emerging economies.

引用

页码：465 / 480

页数：16

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