Applications of eTag®™ assay platform to systems biology approaches in molecular oncology and toxicology studies

被引：18

作者：

Chan-Hui, PY ^{[1
]}

Stephens, K ^{[1
]}

Warnock, RA ^{[1
]}

Singh, S ^{[1
]}

机构：

[1] Aclara BioSci Inc, Mountain View, CA 94043 USA

来源：

CLINICAL IMMUNOLOGY | 2004年 / 111卷 / 02期

关键词：

systems biology; multiplex assay; molecular medicine; molecular oncology; predictive toxicology; gene expression profiling; protein expression profiling; protein phosphorylation; signal transduction pathway network; high throughput screen;

D O I：

10.1016/j.clim.2003.12.015

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We have developed a universal eTag(TM) multiplex assay platfornn that can be uniquely applied to survey the molecule profiles of biologic systems in sub-global large-scale analyses. The effectiveness of eTag(TM) assays when applied to focused system biology studies in molecular oncology and predictive toxicology is herein described while reviewing the Current methods commonly used. The multi-analyte and multiparameter assay approach for parallel analysis will form the basis of an emerging paradigm of multiplexed molecular profiling for signaling pathway networks and various aspects of drug development processes. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：162 / 174

页数：13

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