New feelings about the role of sensory nerves in inflammation

被引：16

作者：

Brain, SD ^{[1
]}

机构：

[1] Kings Coll London, GKT Sch Biomed Sci, Ctr Cardiovasc Biol & Med, London SE1 1UL, England

来源：

NATURE MEDICINE | 2000年 / 6卷 / 02期

关键词：

D O I：

10.1038/72218

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The pro-inflammatory agents trypsin and mast cell tryptase cleave and activate proteinase-activated receptor 2 (PAR2), which is expressed on sensory nerves, explaining a previously unknown mechanism in neurogenic inflammation (151–158).

引用

页码：134 / 135

页数：2

共 11 条

[1]

Bayliss WM, 1901, J PHYSIOL-LONDON, V26, P173

[2]

Böhm SK, 1998, NEWS PHYSIOL SCI, V13, P231

[3] SUBSTANCE-P REGULATES THE VASODILATOR ACTIVITY OF CALCITONIN GENE-RELATED PEPTIDE [J].

BRAIN, SD ;

WILLIAMS, TJ .

NATURE, 1988, 335 (6185) :73-75

[4] CALCITONIN GENE-RELATED PEPTIDE IS A POTENT VASODILATOR [J].

BRAIN, SD ;

WILLIAMS, TJ ;

TIPPINS, JR ;

MORRIS, HR ;

MACINTYRE, I .

NATURE, 1985, 313 (5997) :54-56

[5] The capsaicin receptor: a heat-activated ion channel in the pain pathway [J].

Caterina, MJ ;

Schumacher, MA ;

Tominaga, M ;

Rosen, TA ;

Levine, JD ;

Julius, D .

NATURE, 1997, 389 (6653) :816-824

[6] DIRECT EVIDENCE FOR NEUROGENIC INFLAMMATION AND ITS PREVENTION BY DENERVATION AND BY PRETREATMENT WITH CAPSAICIN [J].

JANCSO, N ;

JANCSOGA.A ;

SZOLCSANYI, J .

BRITISH JOURNAL OF PHARMACOLOGY AND CHEMOTHERAPY, 1967, 31 (01) :138-+

[7]

LEMBECK F, 1979, N-S ARCH PHARMACOL, V310, P175, DOI 10.1007/BF00500282

[8] THE SENSORY-EFFERENT FUNCTION OF CAPSAICIN-SENSITIVE SENSORY NEURONS [J].

MAGGI, CA ;

MELI, A .

GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM, 1988, 19 (01) :1-43

[9] Mast cell activation in children with migraine before and after training in self-regulation [J].

Olness, K ;

Hall, H ;

Rozniecki, JJ ;

Schmidt, W ;

Theoharides, TC .

HEADACHE, 1999, 39 (02) :101-107

[10] Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism [J].

Steinhoff, M ;

Vergnolle, N ;

Young, SH ;

Tognetto, M ;

Amadesi, S ;

Ennes, HS ;

Trevisani, M ;

Hollenberg, MD ;

Wallace, JL ;

Caughey, GH ;

Mitchell, SE ;

Williams, LM ;

Geppetti, P ;

Mayer, EA ;

Bunnett, NW .

NATURE MEDICINE, 2000, 6 (02) :151-158

← 1 2 →