Etiology and pathogenesis of AIDS-related non-Hodgkin's lymphoma

被引：54

作者：

Knowles, DM ^{[1
]}

机构：

[1] CORNELL UNIV MED COLL, DEPT PATHOL, NEW YORK, NY 10021 USA

来源：

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 1996年 / 10卷 / 05期

关键词：

D O I：

10.1016/S0889-8588(05)70386-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Non-Hodgkin's lymphoma (NHL) is the second most common neoplasm that occurs in HIV-infected individuals. Possible factors leading to the development of NHL include HIV-induced immunosuppression, chronic antigenic stimulation, and cytokine overproduction. NHL displays a variety of genetic alterations that vary according to anatomic site of origination and histopathology, suggesting that more than one pathogenic mechanism is operational in the development and progression of NHL. AIDS-related NHL is an important biologic model for investigating the development and progression of high grade NHL as well as NHL that develops in immune deficient hosts.

引用

页码：1081 / +

页数：1

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