Emergence of influenza A H1N2 reassortant viruses in the human population during 2001

被引：60

作者：

Gregory, V

Bennett, M

Orkhan, MH

Al Hajjar, S

Varsano, N

Mendelson, E

Zambon, M

Ellis, J

Hay, A

Lin, YP

机构：

[1] Ridgeway, Div Virol, Natl Inst Med Res, London NW7 1AA, England

[2] Egyptian Org Biol Prod & Vaccines, Cairo, Egypt

[3] King Faisal Specialist Hosp & Res Ctr, Dept Pediat, Riyadh 11211, Saudi Arabia

[4] Chaim Sheba Med Ctr, Cent Virol Lab, Publ Hlth Labs, IL-52621 Tel Hashomer, Israel

[5] PHLS, Cent Publ Hlth Lab, Resp Virus Unit, London NW9 5HT, England

来源：

VIROLOGY | 2002年 / 300卷 / 01期

关键词：

influenza A; human; H1N2; subtype; genetic reassortant;

D O I：

10.1006/viro.2002.1513

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Influenza A H1N2 viruses, which emerged during 2001, are genetic reassortants between H1N1 and H3N2 subtype viruses which have cocirculated in the human population since 1977. They possess a H1 hemagglutinin antigenically and genetically similar to contemporary A/New Caledonia/20/99 (H1N1)-like viruses and seven genes closely related to those of recent A/Moscow/10/99 (H3N2)-like viruses. The viruses have spread to many regions of the world and have predominated over H1N1 viruses in several countries. Since half of the amino acid changes which accumulated in the HAS of H1N1 viruses since 1995 are in residues implicated in receptor binding, functional changes in the Hill HA may have facilitated its replacement of the H3 HA and may contribute to the future epidemiologic significance of these H1N2 viruses. (C) 2002 Elsevier Science (USA).

引用

页码：1 / 7

页数：7

共 20 条

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