Endocytosis of influenza viruses

被引:270
作者
Lakadamyali, M [1 ]
Rust, MJ [1 ]
Zhuang, XW [1 ]
机构
[1] Harvard Univ, Dept Chem & Chem Biol, Cambridge, MA 02138 USA
关键词
influenza; endocytosis; clathrin;
D O I
10.1016/j.micinf.2004.05.002
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Receptor-mediated endocytosis is known to play an important role in the entry of many viruses into host cells. However, the exact internalization mechanism has, until recently, remained poorly understood for many medically important viruses, including influenza. Developments in real-time imaging of single viruses as well as the use of dominant-negative mutants to selectively block specific endocytic pathways have improved our understanding of the influenza infection process. (C) 2004 Elsevier SAS. All rights reserved.
引用
收藏
页码:929 / 936
页数:8
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