Clostridial typhlitis associated with topical antibiotic therapy in a Syrian hamster

被引：2

作者：

Alworth, L. ^{[1
]}

Simmons, J. ^{[2
]}

Franklin, C. ^{[3
]}

Fish, R. ^{[4
]}

机构：

[1] Univ Georgia, Univ Res Anim Resources, Athens, GA 30602 USA

[2] Charles River Labs, Wilmington, MA USA

[3] Univ Missouri, Res Anim Diagnost Lab, Columbia, MO USA

[4] N Carolina State Univ, Coll Vet Med, Raleigh, NC USA

来源：

LABORATORY ANIMALS | 2009年 / 43卷 / 03期

关键词：

Syrian hamster; topical antibiotic ointment; Clostridium difficile; clostridial typhlitis; antibiotic-associated enterotoxaemia; DIFFICILE-ASSOCIATED DIARRHEA; CLINDAMYCIN-ASSOCIATED COLITIS; PSEUDOMEMBRANOUS COLITIS; INTESTINAL MICROFLORA; DISEASE; EPIDEMIOLOGY; VANCOMYCIN; INFECTION; ENTEROCOLITIS; PREVENTION;

D O I：

10.1258/la.2008.008072

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

A Syrian hamster that had been treated with topical antibiotic ointment for 10 days following injuries sustained during fighting was presented moribund. Postmortem and microscopic examinations revealed lesions consistent with clostridial typhlitis and enteritis. Anaerobic culture of caecal contents resulted in the isolation of two Clostridium species, and caecal contents contained Clostridium difficile enterotoxins. Based on these findings, a diagnosis of acute C. difficile, enterotoxaemia was made. This report discusses the pathogenesis of C. difficile enterotoxaemia and the potential role of topical antibiotic ointment therapy in initiating the disease.

引用

页码：304 / 309

页数：6

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