Experimental electroretinographic exploration of retinal ischemia: Preventive use of free radical scavengers and anti-PAF agents

被引：9

作者：

Menerath, JM

Cluzel, J

DroyLefaix, MT

Doly, M

机构：

[1] Fac. de Med. et de Pharmacie, Laboratoire de Biophysique, INSERM U.71, Clermont-Ferrand

[2] Institut IPSEN, Paris

[3] Fac. de Med. et de Pharmacie, Laboratoire de Biophysique, INSERM U.71, 63001 Clermont-FD, Cedex

来源：

JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS | 1997年 / 13卷 / 01期

关键词：

D O I：

10.1089/jop.1997.13.81

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Electroretinographic exploration is an effective approach to evaluate retinal function. In order to investigate physiopathological mechanisms and evaluate potentially protective therapies for retinal ischemia, we developed three experimental models: the first two on isolated retina, with ischemia induced by either stopping perfusion or clamping the ophthalmic artery, and the third, in vivo, with ischemia induced by ocular hypertonia. Since free radicals are implicated in the formation of postischemic lesions, we evaluated the protective effects of drugs known to be free radical scavengers and of an immunomediator antagonist, an anti-PAF (platelet activating factor) agent.

引用

页码：81 / 88

页数：8

共 21 条

[1] INVOLVEMENT OF LEUKOTRIENES AND PAF-ACETHER IN THE INCREASED MICROVASCULAR PERMEABILITY OF THE RABBIT RETINA [J].