Angiotensin II induction of neurite outgrowth by AT(2) receptors in NG108-15, cells - Effect counteracted by the AT(1) receptors

被引:165
作者
Laflamme, L
deGasparo, M
Gallo, JM
Payet, MD
GalloPayet, N
机构
[1] UNIV SHERBROOKE, FAC MED, SERV ENDOCRINOL, SHERBROOKE, PQ J1H 5N4, CANADA
[2] UNIV SHERBROOKE, FAC MED, DEPT PHYSIOL & BIOPHYS, SHERBROOKE, PQ J1H 5N4, CANADA
[3] CIBA GEIGY LTD, DIV PHARMACEUT, DEPT CARDIOVASC RES, BASEL, SWITZERLAND
[4] INST PSYCHIAT, DEPT NEUROL, LONDON SE5 8AF, ENGLAND
[5] UNIV LONDON KINGS COLL, SCH MED & DENT, LONDON SE5 8AF, ENGLAND
关键词
D O I
10.1074/jbc.271.37.22729
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In the present study, 3-day treatment of nondifferentiated NG108-15 cells with 100 nM angiotensin II (Ang II) induces morphological differentiation of neuronal cells characterized by the outgrowth of neurites. These mor morphological changes are correlated with an increase in the level of polymerized tubulin and in the level of the microtubule-associated protein, MAP2c. Mediation by the AT(2) receptor may be inferred since: (a) these cells contain only AT(2) receptors; (b) the effects are mimicked by CGP 42112 (an AT(2) receptor agonist); (c) they are not suppressed by the addition of DUP 753 (an AT(1) receptor antagonist); and (d) are abolished by co-incubation with PD 123319 (an AT(2) receptor antagonist). Application of Ang II in dibutyryl cAMP-differentiated cells (which contain both types of receptors) induces neurite retraction, an effect mediated by the AT(1) receptor. These results indicate that the AT(2) receptor of Ang II induces neuronal differentiation, which is initiated through an increase in the levels of MAP2c associated with tubulin. Moreover, our results demonstrate that the AT(1) receptor inhibit the process of differentiation induced by dibutyryl cAMP, whereas the AT(2) receptors potentiate this effect, illustrating negative cross-talk interaction between the two types of Ang II receptors.
引用
收藏
页码:22729 / 22735
页数:7
相关论文
共 54 条
[1]   IDENTIFICATION AND CHARACTERIZATION OF ANGIOTENSIN-II RECEPTOR SUBTYPES IN HUMAN BRAIN [J].
BARNES, JM ;
STEWARD, LJ ;
BARBER, PC ;
BARNES, NM .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1993, 230 (03) :251-258
[2]   DISTINCT MODE OF MICROTUBULE-ASSOCIATED PROTEIN-2 EXPRESSION IN THE NEUROBLASTOMA-GLIOMA CELL-LINE 108CC15/NG108-15 [J].
BEAMANHALL, CM ;
VALLANO, ML .
JOURNAL OF NEUROBIOLOGY, 1993, 24 (11) :1500-1516
[3]  
BINDER LI, 1985, J CELL BIOL, V101, P1371, DOI 10.1083/jcb.101.4.1371
[4]   ANGIOTENSIN-II RECEPTOR SUBTYPES - CHARACTERIZATION, SIGNALING MECHANISMS, AND POSSIBLE PHYSIOLOGICAL IMPLICATIONS [J].
BOTTARI, SP ;
DEGASPARO, M ;
STECKELINGS, UM ;
LEVENS, NR .
FRONTIERS IN NEUROENDOCRINOLOGY, 1993, 14 (02) :123-171
[5]  
BRECHLER V, 1994, RECEPTOR CHANNEL, V2, P89
[6]   THE ANGIOTENSIN AT2-RECEPTOR MODULATES T-TYPE CALCIUM CURRENT IN NONDIFFERENTIATED NG108-15 CELLS [J].
BUISSON, B ;
BOTTARI, SP ;
DEGASPARO, M ;
GALLOPAYET, N ;
PAYET, MD .
FEBS LETTERS, 1992, 309 (02) :161-164
[7]   A G-PROTEIN IS INVOLVED IN THE ANGIOTENSIN AT(2) RECEPTOR INHIBITION OF THE T-TYPE CALCIUM CURRENT IN NON-DIFFERENTIATED NG108-15 CELLS [J].
BUISSON, B ;
LAFLAMME, L ;
BOTTARI, SP ;
DEGASPARO, M ;
GALLOPAYET, N ;
PAYET, MD .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (04) :1670-1674
[8]   SUPPRESSION OF MAP2 IN CULTURED CEREBELLAR MACRONEURONS INHIBITS MINOR NEURITE FORMATION [J].
CACERES, A ;
MAUTINO, J ;
KOSIK, KS .
NEURON, 1992, 9 (04) :607-618
[9]   INHIBITION OF NEURITE POLARITY BY TAU ANTISENSE OLIGONUCLEOTIDES IN PRIMARY CEREBELLAR NEURONS [J].
CACERES, A ;
KOSIK, KS .
NATURE, 1990, 343 (6257) :461-463
[10]   CHARACTERIZATION OF A HIGH-AFFINITY, GUANINE-NUCLEOTIDE SENSITIVE ANGIOTENSIN RECEPTOR ON DIFFERENTIATED NEUROBLASTOMA GLIOMA HYBRID-CELLS (NG108-15) [J].
CARRITHERS, MD ;
MASUDA, S ;
KOIDE, KA ;
WEYHENMEYER, JA .
NEUROSCIENCE LETTERS, 1992, 135 (01) :45-48