Kaposi's sarcoma following malignant mesothelioma

被引：7

作者：

Ascoli, V

Scalzo, CC

Andreoni, M

Manente, L

Pistilli, A

Lo Coco, F

机构：

[1] Univ La Sapienza, Dept Expt Med & Pathol, I-00161 Rome, Italy

[2] Univ La Sapienza, Dept Hematol & Biotechnol, Rome, Italy

[3] Univ Rome Tor Vergata, Dept Publ Hlth, Rome, Italy

[4] Hosp Colleferro, Rome, Italy

来源：

VIRCHOWS ARCHIV-AN INTERNATIONAL JOURNAL OF PATHOLOGY | 1999年 / 435卷 / 06期

关键词：

Kaposi sarcoma; mesothelioma; interleukin-6; platelet-derived growth factor; herpes virus; Kaposi-sarcoma associated;

D O I：

10.1007/s004280050448

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

We report the unusual occurrence of Kaposi's sarcoma following asbestos-related malignant mesothelioma, in a human deficiency virus (HIV)-negative Italian man. Seropositivity to human herpes virus 8 (HHV8) was documented at the time of mesothelioma diagnosis and preceded the onset of Kaposi' sarcoma with a time lapse of 13 months. HHV8 DNA was detected by polymerase chain reaction in lesional Kaposi's sarcoma but not within mesothelioma. By immunostaining, mesothelioma cells expressed interleukin-6 and platelet-derived growth factor, which are important for survival of Kaposi's sarcoma cells. Besides the possibility of a casual association, we hypothesize that mesothelioma-linked factors may have contributed to the development of Kaposi' sarcoma in the presence of HHV8 infection.

引用

页码：612 / 615

页数：4

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