Development of the mammary gland requires DGAT1 expression in stromal and epithelial tissues

被引：41

作者：

Cases, S ^{[1
]}

Zhou, P

Shillingford, JM

Wiseman, BS

Fish, JD

Angle, CS

Hennighausen, L

Werb, Z

Farese, RV

机构：

[1] Univ Calif San Francisco, Gladstone Inst Cardiovasc Dis, San Francisco, CA 94141 USA

[2] Univ Calif San Francisco, Cardiovasc Res Inst, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Dept Anat, San Francisco, CA 94143 USA

[4] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA

[5] NIDDK, Lab Genet & Physiol, Natl Inst Hlth, Bethesda, MD 20892 USA

来源：

DEVELOPMENT | 2004年 / 131卷 / 13期

关键词：

mammary gland; acyl CoA : diacylglycerol acyl transferase; lipid; triacylglycerol;

D O I：

10.1242/dev.01158

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Mammary gland development is a complex process that is dependent on interactions between the developing mammary epithelium and the surrounding stromal tissues. We show that mice lacking the triglyceride synthesis enzyme acyl CoA:diacylglycerol transferase 1 (DGAT1) have impaired mammary gland development, characterized by decreased epithelial proliferation and alveolar development, and reduced expression of markers of functional differentiation. Transplantation studies demonstrate that the impaired development results from a deficiency of DGAT1. in both the stromal and epithelial tissues. Our findings are the first to link defects in stromal lipid metabolism to impaired mammary gland development.

引用

页码：3047 / 3055

页数：9

共 45 条

[1] Rescue of mammary epithelial cell apoptosis and entactin degradation by a tissue inhibitor of metalloproteinases-1 transgene [J].

Alexander, CM ;

Howard, EW ;

Bissell, MJ ;

Werb, Z .

JOURNAL OF CELL BIOLOGY, 1996, 135 (06) :1669-1677

[2] ENZYMES OF GLYCEROLIPID SYNTHESIS IN EUKARYOTES [J].

BELL, RM ;

COLEMAN, RA .

ANNUAL REVIEW OF BIOCHEMISTRY, 1980, 49 :459-487

[3]

Brindley D. N., 1991, BIOCH LIPIDS LIPOPRO, P171, DOI 10.1016/S0167-7306(08)60334-8

[4] Prolactin controls mammary gland development via direct and indirect mechanisms [J].

Brisken, C ;

Kaur, S ;

Chavarria, TE ;

Binart, N ;

Sutherland, RL ;

Weinberg, RA ;

Kelly, PA ;

Ormandy, CJ .

DEVELOPMENTAL BIOLOGY, 1999, 210 (01) :96-106

[5] Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis [J].

Cases, S ;

Smith, SJ ;

Zheng, YW ;

Myers, HM ;

Lear, SR ;

Sande, E ;

Novak, S ;

Collins, C ;

Welch, CB ;

Lusis, AJ ;

Erickson, SK ;

Farese, RV .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (22) :13018-13023

[6] Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family members [J].

Cases, S ;

Stone, SJ ;

Zhou, P ;

Yen, E ;

Tow, B ;

Lardizabal, KD ;

Voelker, T ;

Farese, RV .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (42) :38870-38876

[7]

Chen HC, 2003, J CLIN INVEST, V111, P1715, DOI 10.1172/JCI15859

[8]

Chen HC, 2002, J CLIN INVEST, V109, P1049, DOI 10.1172/JCI0214672

[9] Sexual differentiation, pregnancy, calorie restriction, and aging affect the adipocyte-specific secretory protein adiponectin [J].

Combs, TP ;

Berg, AH ;

Rajala, MW ;

Klebanov, S ;

Iyengar, P ;

Jimenez-Chillaron, JC ;

Patti, ME ;

Klein, SL ;

Weinstein, RS ;

Scherer, PE .

DIABETES, 2003, 52 (02) :268-276

[10] Adipose tissue: A vital in vivo role in mammary gland development but not differentiation [J].

Couldrey, C ;

Moitra, J ;

Vinson, C ;

Anver, M ;

Nagashima, K ;

Green, J .

DEVELOPMENTAL DYNAMICS, 2002, 223 (04) :459-468

← 1 2 3 4 5 →