Interleukin-6 and insulin sensitivity: friend or foe?

被引：99

作者：

Carey, AL ^{[1
]}

Febbraio, MA ^{[1
]}

机构：

[1] RMIT Univ, Sch Med Sci, Skeletal Muscle Res Lab, Bundoora, Vic 3083, Australia

来源：

DIABETOLOGIA | 2004年 / 47卷 / 07期

基金：

英国医学研究理事会;

关键词：

adipocyte; cytokines; glucose transport; hepatic; insulin resistance; skeletal muscle;

D O I：

10.1007/s00125-004-1447-y

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

[No abstract available]

引用

页码：1135 / 1142

页数：8

共 95 条

[1]

ANDUS T, 1991, HEPATOLOGY, V13, P364, DOI 10.1016/0270-9139(91)92454-G

[2] Adipose tissue IL-6 content correlates with resistance to insulin activation of glucose uptake both in vivo and in vitro [J].

Bastard, JP ;

Maachi, M ;

Van Nhieu, JT ;

Jardel, C ;

Bruckert, E ;

Grimaldi, A ;

Robert, JJ ;

Capeau, J ;

Hainque, B .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2002, 87 (05) :2084-2089

[3] Elevated levels of interleukin 6 are reduced in serum and subcutaneous adipose tissue of obese women after weight loss [J].

Bastard, JP ;

Jardel, C ;

Bruckert, E ;

Blondy, P ;

Capeau, J ;

Laville, M ;

Vidal, H ;

Hainque, B .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2000, 85 (09) :3338-3342

[4]

CAMPBELL IL, 1989, J IMMUNOL, V143, P1188

[5] Interleukin-6 gene expression is increased in insulin-resistant rat skeletal muscle following insulin stimulation [J].

Carey, AL ;

Lamont, B ;

Andrikopoulos, S ;

Koukoulas, I ;

Proietto, J ;

Febbraio, MA .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2003, 302 (04) :837-840

[6] Interleukin-6 and tumor necrosis factor-α are not increased in patients with Type 2 diabetes:: evidence that plasma interleukin-6 is related to fat mass and not insulin responsiveness [J].

Carey, AL ;

Bruce, CR ;

Sacchetti, M ;

Anderson, MJ ;

Olsen, DB ;

Saltin, B ;

Hawley, JA ;

Febbraio, MA .

DIABETOLOGIA, 2004, 47 (06) :1029-1037

[7] Interleukin-6 inhibits transforming growth factor-β-induced apoptosis through the phosphatidylinositol 3-kinase/Akt and signal transducers and activators of transcription 3 pathways [J].

Chen, RH ;

Chang, MC ;

Su, YH ;

Tsai, YT ;

Kuo, ML .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (33) :23013-23019

[8] INHIBITION BY RECOMBINANT HUMAN INTERLEUKIN-6 OF THE GLUCAGON-DEPENDENT INDUCTION OF PHOSPHOENOLPYRUVATE CARBOXYKINASE AND OF THE INSULIN-DEPENDENT INDUCTION OF GLUCOKINASE GENE-EXPRESSION IN CULTURED RAT HEPATOCYTES - REGULATION OF GENE-TRANSCRIPTION AND MESSENGER-RNA DEGRADATION [J].

CHRIST, B ;

NATH, A ;

HEINRICH, PC ;

JUNGERMANN, K .

HEPATOLOGY, 1994, 20 (06) :1577-1583

[9] EFFECTS OF INSULIN ON PERIPHERAL AND SPLANCHNIC GLUCOSE-METABOLISM IN NONINSULIN-DEPENDENT (TYPE-II) DIABETES-MELLITUS [J].

DEFRONZO, RA ;

GUNNARSSON, R ;

BJORKMAN, O ;

OLSSON, M ;

WAHREN, J .

JOURNAL OF CLINICAL INVESTIGATION, 1985, 76 (01) :149-155

[10]

DEVIERE J, 1989, CLIN EXP IMMUNOL, V77, P221

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