Effect of enalapril maleate on cerebral blood flow in patients with chronic heart failure

被引:19
作者
Kamishirado, H [1 ]
Inoue, T [1 ]
Fujito, T [1 ]
Kase, M [1 ]
Shimizu, M [1 ]
Sakai, Y [1 ]
Takayanagi, K [1 ]
Morooka, S [1 ]
Natsui, ST [1 ]
机构
[1] DOKKYO UNIV, SCH MED, KOSHIGAYA HOSP, DEPT RADIOL, KOSHIGAYA, SAITAMA 343, JAPAN
关键词
D O I
10.1177/000331979704800806
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
The effect of enalapril on cerebral blood flow (CBF) was studied in 11 patients with chronic heart failure (NYHA II pr III, dilated cardiomyopathy in 6 and old myocardial infarction in 5). CBF was evaluated by analyzing the Patlak-Plot curve obtained from radionuclide angiography with technetium-99m hexamethylpropylene amine oxime (Tc-99m-HM-PAO). Cardiac index (CI) and stroke volume (SV) were simultaneously measured by impedance cardiography. These measurements were performed before and at four weeks after daily administration of 5 mg enalapril. The stroke volume, cardiac index, and heart rate were not significantly changed after four weeks of enalapril administration. However, CBF was increased by 6.5% from 36.72 +/-4.66 to 39.13 +/-5.65 mL/100g/min (P<0.05). These results suggest that enalapril increased cerebral blood flow, which was not related to increased cardiac output in congestive heart failure. Patlak-Plot analysis of radionuclide angiography using Tc-99m-HM-PAO may be available for quantitative assessment of brain perfusion.
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页码:707 / 713
页数:7
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