A one-flask synthesis of α,α-bisphosphonates via enolate chemistry

被引：24

作者：

Du, YM

Jung, KY

Wiemer, DF ^{[1
]}

机构：

[1] Univ Iowa, Dept Chem, Iowa City, IA 52242 USA

[2] Kangnung Natl Univ, Dept Environm & Appl Chem, Kangnung, Kangwon Do, South Korea

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 48期

关键词：

D O I：

10.1016/S0040-4039(02)02148-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Treatment of several carbonyl compounds with excess strong base and diethyl phosphorochloridite results in formation of two carbon-phosphorus bonds at the alpha carbon. Oxidation of the immediate product with H2O2 affords the corresponding alpha,alpha-bisphosphonate in moderate to very good yields. (C) 2002 Published by Elsevier Science Ltd.

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页码：8665 / 8668

页数：4

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