Pervanadate elicits proliferation and mediates activation of mitogen-activated protein (MAP) kinase in the nucleus

被引:23
作者
Krady, MM [1 ]
Freyermuth, S [1 ]
Rogue, P [1 ]
Malviya, AN [1 ]
机构
[1] CTR NEUROCHIM,UPR 416 CNRS,LAB NEUROBIOL MOL INTERACT CELLULAIRES,F-67084 STRASBOURG,FRANCE
关键词
protein tyrosine phosphatase; protein tyrosine kinase; pervanadate; mitogen-activated protein kinase; TPA; proliferation; differentiation; C3H10T1/2 mouse fibroblast;
D O I
10.1016/S0014-5793(97)00821-1
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
There is growing evidence for the role of protein tyrosine phosphatases in controlling such fundamental cellular processes as growth and differentiation. Pervanadate is a potent inhibitor of protein tyrosine phosphatase which has been observed here to induce proliferation in C3H10T1/2 mouse fibroblasts, Pervanadate also translocated/activated p42/44 mitogen-activated protein (MAP) kinase to the cell nucleus, An almost similar pattern of nuclear p42/44 MAP kinase stimulation is seen with TPA. On the other hand, TPA treatment results in a rapid activation of cytosolic MAP kinase which declines with time. Thus pervanadate appears as a very useful tool for studying tyrosine phosphorylation. (C) 1997 Federation of European Biochemical Societies.
引用
收藏
页码:420 / 424
页数:5
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