The emerging role of monitoring serum HER-2/neu oncoprotein levels in women with metastatic breast cancer

被引：12

作者：

Carney, WP ^{[1
]}

机构：

[1] Oncogene Sci, Cambridge, MA USA

来源：

LABORATORY MEDICINE | 2003年 / 34卷 / 01期

关键词：

D O I：

10.1309/TY6M-DWB0-G2BU-6D5F

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

The HER-2/neu oncogene encodes a transmembrane growth factor receptor protein that is overexpressed in a variety of cancer cells. The HER-2/neu oncoprotein has become a major target for the development of new cancer therapies. Studies show that monitoring serum HER-2/neu levels during metastatic breast cancer can provide a real-time assessment of a woman's HER-2/neu status and can provide important information for making therapeutic decisions.

引用

页码：58 / 64

页数：7

共 30 条

[1] DETECTION OF C-ERBB-2 RELATED PROTEIN IN SERA FROM BREAST-CANCER PATIENTS - RELATIONSHIP TO ERBB2 GENE AMPLIFICATION AND C-ERBB-2 PROTEIN OVEREXPRESSION IN TUMOR
ANDERSEN, TI
PAUS, E
NESLAND, JM
MCKENZIE, SJ
BORRESEN, AL
[J]. ACTA ONCOLOGICA, 1995, 34 (04) : 499 - 504
[2] BRANDTRAUF PW, 1995, CRITICAL REV ONCOGEN, P313
[3] CARNEY W P, 1991, Journal of Tumor Marker Oncology, V6, P53
[4] Cook GB, 2001, ANTICANCER RES, V21, P1465
[5] COUSSEN SL, 1985, SCIENCE, P1132
[6] DA NO, 1995, ONCOLOGY, V52, P392
[7] Phase II study of weekly docetaxel and trastuzumab for patients with HER-2-overexpressing metastatic breast cancer
Esteva, FJ
Valero, V
Booser, D
Guerra, LT
Murray, JL
Pusztai, L
Cristofanilli, M
Arun, B
Esmaeli, B
Fritsche, HA
Sneige, N
Smith, TL
Hortobagyi, GN
[J]. JOURNAL OF CLINICAL ONCOLOGY, 2002, 20 (07) : 1800 - 1808
[8] HAYES D F, 1989, Breast Cancer Research and Treatment, V14, P135
[9] KAPTAIN S, 2001, DIAGNOSTIC MOL PATHO, P139
[10] Krainer M, 1997, ONCOLOGY, V54, P475

← 1 2 3 →