An intrinsic host defense against HIV-1 integration?

被引：9

作者：

Bieniasz, Paul D.

机构：

[1] Rockefeller Univ, Arnold Diamond AIDS Res Ctr, New York, NY 10016 USA

[2] Rockefeller Univ, Lab Retrovirol, New York, NY 10016 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2007年 / 117卷 / 02期

关键词：

D O I：

10.1172/JCI31290

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

HSCs are one of only a few cell types that resist HIV-1 infection despite the presence of HIV-1 receptors. An increasing number of genes have been identified that can reduce the sensitivity of cultured cells to retrovirus infection, and in this issue of the JCI, Zhang et al. identify p21(Waf1/Cip1/Sdi1) (p21) as a gene product that can influence the sensitivity of HSCs to HIV-1 infection (see the related article beginning on page 473). Strikingly, p21 appears to alter the fate of nuclear HIV-1 DNA, promoting the formation of circular viral DNA forms rather than functional proviruses.

引用

收藏

页码：302 / 304

页数：3

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