The long and short of colicin action: The molecular basis for the biological activity of channel-forming colicins

被引：30

作者：

Gouaux, E

机构：

[1] Dept. Biochem. and Molec. Biophys., Columbia University, New York, NY 10032

来源：

STRUCTURE | 1997年 / 5卷 / 03期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0969-2126(97)00188-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Channel-forming colicins undergo a remarkable series of conformational gyrations during their voyage from the extracellular milieu to the periplasmic membrane, Crystal structures of the intact colicin la molecule and a channel-forming domain of colicin El illuminate relationships between the molecular structure and biological function of these voltage-dependent channel-forming toxins.

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收藏

页码：313 / 317

页数：5

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