DNA repair: Bioinformatics helps reverse methylation damage

被引：8

作者：

Jiricny, J

机构：

[1] Univ Zurich, Inst Med Radiobiol, CH-8008 Zurich, Switzerland

[2] Paul Scherrer Inst, CH-8008 Zurich, Switzerland

来源：

CURRENT BIOLOGY | 2002年 / 12卷 / 24期

关键词：

D O I：

10.1016/S0960-9822(02)01350-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent work has uncovered a novel DNA repair enzyme: the AlkB protein of Escherichia coli, which oxidises the methyl groups of 1-methyladenine and 3-methylcytosine to hydroxymethyl moieties; the oxidised groups are subsequently released as formaldehyde, regenerating the unmodified bases.

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收藏

页码：R846 / R848

页数：3

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