Acridone and furoquinoline alkaloids from Teclea gerrardii (Rutaceae: Toddalioideae) of southern Africa

被引：37

作者：

Kamdem Waffo, Alain F.

Coombes, Philip H.

Crouch, Neil R.

Mulholland, Dulcie A.

El Amin, Sawsan M. M.

Smith, Peter J.

机构：

[1] Univ KwaZulu Natal, Sch Chem, ZA-4041 Durban, South Africa

[2] Univ Douala, Fac Sci, Dept Chem, Douala, Cameroon

[3] Univ Surrey, Sch Biomed & Mol Sci, Guildford GU2 7XH, Surrey, England

[4] Univ Cape Town, Dept Med, Div Pharmacol, ZA-7295 Observatory, South Africa

来源：

PHYTOCHEMISTRY | 2007年 / 68卷 / 05期

基金：

新加坡国家研究基金会;

关键词：

Teclea gerrardii; Rutaceae; stem bark; acridone alkaloids; furoquinoline alkaloids; 3-hydroxy-1-methoxy-N-methylacridone (tegerrardin A); 3-hydroxy-N-methyl-1-(gamma; gamma-dimethylallyloxy)acridone (tegerrardin B); arborinine; evoxanthine; 1,3-dimethoxy-N-methylacridone; evoxine; 7-(gamma; gamma-dimethylallyloxy)-gamma-fagarine; tecleanone; Plasmodium falciparum; antiplasmodial activity;

D O I：

10.1016/j.phytochem.2006.10.011

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The combined hexane/CH2Cl2 extract of the stem bark of Teclea gerrardii (Rutaceae: Toddalioideae) has yielded two acridone alkaloids, 3-hydroxy-1-methoxy-N-methylacridone (tegerrardin A) (1) and 3-hydroxy-N-methyl-1-(gamma,gamma-dimethylallyloxy)acridone (tegerrardin B) (2), three known acridones (3-5), two known furoquinolines (6,7), and the acridone precursor teclearione (8). Arborinine (3) and evoxine (6) displayed moderate antiplasmodial activity against the CQS D 10 strain of Plasmodium falciparum, with IC50 values of 12.3 and 24.5 mu M, respectively. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：663 / 667

页数：5

共 39 条

[1] Furoquinoline alkaloids from Teclea nobilis [J].