Synthesis, structural characterization, and antitumor activity of palladium(II) complexes containing a sugar unit

被引：56

作者：

Brudziñska, I

Mikata, Y ^{[1
]}

Obata, M

Ohtsuki, C

Yano, S

机构：

[1] Nara Womens Univ, Grad Sch Humanities & Sci, Div Mat Sci, Nara 6308506, Japan

[2] Nara Womens Univ, KYOUSEI Sci Ctr, Nara 6308506, Japan

[3] Nara Inst Sci & Technol, Grad Sch Mat Sci, Nara 6300101, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 10期

关键词：

palladium; cisplatin; carbohydrate; antitumor activity;

D O I：

10.1016/j.bmcl.2004.02.095

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Six palladium(II) complexes as cisplatin derivatives with a sugar unit (D-glucose, D-galactose, D-mannose, D-Xylose, and maltose) have been prepared. The structural features of the complexes have been characterized by NMR spectroscopy, elemental analysis, mass spectroscopy, and X-ray crystallography. The complexes have been tested for in vivo cytotoxicity against P388 cells implanted in mice. All of Pd compounds are apparently nontoxic. A T/C value of 120% was obtained for maltose derivative at the dose of 400mg/kg, which indicates that the compound may be endowed with antitumor activity. (C) 2004 Elsevier Ltd. All rights reserved.

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页码：2533 / 2536

页数：4

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